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Verfasst von:Stefanovic, Stefan [VerfasserIn]   i
 Wirtz, Ralph [VerfasserIn]   i
 Sütterlin, Marc [VerfasserIn]   i
 Karic, Uros [VerfasserIn]   i
 Schneeweiss, Andreas [VerfasserIn]   i
 Deutsch, Thomas M. [VerfasserIn]   i
 Wallwiener, Markus [VerfasserIn]   i
Titel:Cut-off analysis of HLA-A and HLA-B/C expression as a potential prognosticator of favorable survival in patients with metastatic breast cancer
Verf.angabe:Stefan Stefanovic, Ralph Wirtz, Marc Sütterlin, Uros Karic, Andreas Schneeweiss, Thomas M. Deutsch, Markus Wallwiener
E-Jahr:2023
Jahr:March 27, 2023
Umfang:6 S.
Fussnoten:Gesehen am 21.06.2023
Titel Quelle:Enthalten in: Anticancer research
Ort Quelle:Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004
Jahr Quelle:2023
Band/Heft Quelle:43(2023), 4 vom: März, Seite 1449-1454
ISSN Quelle:1791-7530
Abstract:Background/Aim: Loss of differentiation of breast cancer cells in association with a down-regulated class I human leukocyte antigen (HLA) expression can lead to proliferation unhampered by cytotoxic T lymphocytes, which has been proven to be of prognostic relevance. The objective of this study was to determine the levels of HLA-A and HLA-B/C expression in metastatic breast cancer (MBC) cells and their usefulness for predicting 5-year survival. Materials and Methods: This prospective double-blinded cohort study analyzed patients starting a new line of therapy for MBC. RT-qPCR was used to determine the levels of HLA-A and B/C expression in MBC cells and the mRNA-based tumor intrinsic subtype. Two receiver operating characteristic curves (ROC) were constructed in order to determine whether HLA-A and HLA-B/C expression levels can be used for predicting 5-year survival. Youden J points, and sensitivity and specificity optimized cut-off points were determined for both ROC curves. Results: We enrolled 34 patients. The ROC curve for HLA-B/C had the highest AUC compared to HLA-A (0.55 vs. 0.42). High levels of HLA-A and HLA-B/C expression (40-ΔΔCT of 33.5 and 31.9, respectively) were highly specific (reaching 87.5% for HLA-A and even 100% specificity for HLA-B/C) yet insensitive for five-year survival in our study. Conclusion: High expression of certain class I HLA molecule subtypes by MBCs, in particular high HLA-A or B/C expression by MBC cells seems very specific in predicting the 5-year survival. We determined cut-off values for these HLA molecule clusters with high specificity, which might help identify patients with a favorable prognosis as prognosticators of a 5-year overall survival if their sensitivity is improved in larger prospective cohorts.
DOI:doi:10.21873/anticanres.16293
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.21873/anticanres.16293
 Volltext: https://ar.iiarjournals.org/content/43/4/1449
 DOI: https://doi.org/10.21873/anticanres.16293
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Breast cancer
 cut-off
 HLA-A
 HLA-B/C
 prognosticator
K10plus-PPN:185071309X
Verknüpfungen:→ Zeitschrift

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