| Online-Ressource |
Verfasst von: | Stefanovic, Stefan [VerfasserIn]  |
| Wirtz, Ralph [VerfasserIn]  |
| Sütterlin, Marc [VerfasserIn]  |
| Karic, Uros [VerfasserIn]  |
| Schneeweiss, Andreas [VerfasserIn]  |
| Deutsch, Thomas M. [VerfasserIn]  |
| Wallwiener, Markus [VerfasserIn]  |
Titel: | Cut-off analysis of HLA-A and HLA-B/C expression as a potential prognosticator of favorable survival in patients with metastatic breast cancer |
Verf.angabe: | Stefan Stefanovic, Ralph Wirtz, Marc Sütterlin, Uros Karic, Andreas Schneeweiss, Thomas M. Deutsch, Markus Wallwiener |
E-Jahr: | 2023 |
Jahr: | March 27, 2023 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 21.06.2023 |
Titel Quelle: | Enthalten in: Anticancer research |
Ort Quelle: | Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 43(2023), 4 vom: März, Seite 1449-1454 |
ISSN Quelle: | 1791-7530 |
Abstract: | Background/Aim: Loss of differentiation of breast cancer cells in association with a down-regulated class I human leukocyte antigen (HLA) expression can lead to proliferation unhampered by cytotoxic T lymphocytes, which has been proven to be of prognostic relevance. The objective of this study was to determine the levels of HLA-A and HLA-B/C expression in metastatic breast cancer (MBC) cells and their usefulness for predicting 5-year survival. Materials and Methods: This prospective double-blinded cohort study analyzed patients starting a new line of therapy for MBC. RT-qPCR was used to determine the levels of HLA-A and B/C expression in MBC cells and the mRNA-based tumor intrinsic subtype. Two receiver operating characteristic curves (ROC) were constructed in order to determine whether HLA-A and HLA-B/C expression levels can be used for predicting 5-year survival. Youden J points, and sensitivity and specificity optimized cut-off points were determined for both ROC curves. Results: We enrolled 34 patients. The ROC curve for HLA-B/C had the highest AUC compared to HLA-A (0.55 vs. 0.42). High levels of HLA-A and HLA-B/C expression (40-ΔΔCT of 33.5 and 31.9, respectively) were highly specific (reaching 87.5% for HLA-A and even 100% specificity for HLA-B/C) yet insensitive for five-year survival in our study. Conclusion: High expression of certain class I HLA molecule subtypes by MBCs, in particular high HLA-A or B/C expression by MBC cells seems very specific in predicting the 5-year survival. We determined cut-off values for these HLA molecule clusters with high specificity, which might help identify patients with a favorable prognosis as prognosticators of a 5-year overall survival if their sensitivity is improved in larger prospective cohorts. |
DOI: | doi:10.21873/anticanres.16293 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.21873/anticanres.16293 |
| Volltext: https://ar.iiarjournals.org/content/43/4/1449 |
| DOI: https://doi.org/10.21873/anticanres.16293 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Breast cancer |
| cut-off |
| HLA-A |
| HLA-B/C |
| prognosticator |
K10plus-PPN: | 185071309X |
Verknüpfungen: | → Zeitschrift |
Cut-off analysis of HLA-A and HLA-B/C expression as a potential prognosticator of favorable survival in patients with metastatic breast cancer / Stefanovic, Stefan [VerfasserIn]; March 27, 2023 (Online-Ressource)