Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Royston, Patrick [VerfasserIn]  |
| Sauerbrei, Wilhelm F. [VerfasserIn]  |
| Becher, Heiko [VerfasserIn]  |
Titel: | Modelling continuous exposures with a "spike" at zero |
Titelzusatz: | a new procedure based on fractional polynomials |
Verf.angabe: | Patrick Royston, Willi Sauerbrei and Heiko Becher |
E-Jahr: | 2010 |
Jahr: | 26 February 2010 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 22.06.2023 |
Titel Quelle: | Enthalten in: Statistics in medicine |
Ort Quelle: | Chichester [u.a.] : Wiley, 1982 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 29(2010), 11 vom: Mai, Seite 1219-1227 |
ISSN Quelle: | 1097-0258 |
Abstract: | A common task in epidemiology is to estimate the dose-response function for a continuous exposure. Often a proportion of subjects is unexposed. Typical examples are cigarette consumption, alcohol intake, or occupational exposures. The question arises as to how to model such variables statistically. The fractional polynomial method of modelling continuous exposure variables is extended to allow for a proportion unexposed. A binary variable for the unexposed fraction is added to the model. In a two-stage procedure, we assess whether the binary variable and/or the continuous function for the exposed individuals is required for a good fit to the data. Extension to the multivariable situation is described. Three data sets with different characteristics are used as illustrations. The analyses of the three studies using the proposed procedure give differing results. In one example, only the binary variable seems to be required. In the other two examples, the binary variable and fractional polynomial functions of the exposure variable are needed. One function is monotonic and the other has a minimum. In the third example, adjusting for confounders has almost no effect on the function selected. In conclusion, the new procedure offers a worthwhile extension of dose-response modelling with an unexposed fraction. It is simple to carry out with standard software. Copyright © 2010 John Wiley & Sons, Ltd. |
DOI: | doi:10.1002/sim.3864 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/sim.3864 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/sim.3864 |
| DOI: https://doi.org/10.1002/sim.3864 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | confounders |
| dose-response model |
| fraction unexposed |
| fractional polynomials |
| regression modelling |
K10plus-PPN: | 185079779X |
Verknüpfungen: | → Zeitschrift |
Modelling continuous exposures with a "spike" at zero / Royston, Patrick [VerfasserIn]; 26 February 2010 (Online-Ressource)
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