| |  Online-Ressource |
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| Verfasst von: | Parlato, Rosanna [VerfasserIn]  |
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| | Cruz, Hans [VerfasserIn] |
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| | Otto, Christiane [VerfasserIn] |
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| | Murtra, Patricia [VerfasserIn] |
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| | Rodriguez-Parkitna, Jan [VerfasserIn] |
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| | Martin, Miquel [VerfasserIn] |
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| | Bura, Simona A. [VerfasserIn] |
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| | Begus-Nahrmann, Yvonne [VerfasserIn] |
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| | Von Bohlen und Halbach, Oliver [VerfasserIn] |
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| | Maldonado, Rafael [VerfasserIn] |
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| | Schütz, Günther [VerfasserIn] |
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| | Lüscher, Christian [VerfasserIn] |
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| Titel: | Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine |
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| Verf.angabe: | Rosanna Parlato, Hans Cruz, Christiane Otto, Patricia Murtra, Jan Rodriguez Parkitna, Miquel Martin, Simona A. Bura, Yvonne Begus-Nahrmann, Oliver Von Bohlen und Halbach, Rafael Maldonado, Günther Schütz and Christian Lüscher |
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| E-Jahr: | 2010 |
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| Jahr: | 29 March 2010 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 26.06.2023 |
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| Titel Quelle: | Enthalten in: Journal of neurochemistry |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1956 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 115(2010), 3 vom: Nov., Seite 563-573 |
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| ISSN Quelle: | 1471-4159 |
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| Abstract: | J. Neurochem. (2010) 115, 563-573. Abstract Repeated exposure to opiates leads to cellular and molecular changes and behavioral alterations reflecting a state of dependence. In noradrenergic neurons, cyclic AMP (cAMP)-dependent pathways are activated during opiate withdrawal, but their contribution to the activity of locus coeruleus noradrenergic neurons and behavioral manifestations remains controversial. Here, we test whether the cAMP-dependent transcription factors cAMP responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) in noradrenergic neurons control the cellular markers and the physical signs of morphine withdrawal in mice. Using the Cre/loxP system we ablated the Creb1 gene in noradrenergic neurons. To avoid adaptive effects because of compensatory up-regulation of CREM, we crossed the conditional Creb1 mutant mice with a Crem−/− line. We found that the enhanced expression of tyrosine hydroxylase normally observed during withdrawal was attenuated in CREB/CREM mutants. Moreover, the withdrawal-associated cellular hyperactivity and c-fos expression was blunted. In contrast, naloxone-precipitated withdrawal signs, such as jumping, paw tremor, tremor and mastication were preserved. We conclude by a specific genetic approach that the withdrawal-associated hyperexcitability of noradrenergic neurons depends on CREB/CREM activity in these neurons, but does not mediate several behavioral signs of morphine withdrawal. |
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| DOI: | doi:10.1111/j.1471-4159.2010.06709.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1111/j.1471-4159.2010.06709.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2010.06709.x |
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| | DOI: https://doi.org/10.1111/j.1471-4159.2010.06709.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cre/LoxP |
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| | cyclic AMP |
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| | locus coeruleus |
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| | morphine dependence |
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| K10plus-PPN: | 185096873X |
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| Verknüpfungen: | → Zeitschrift |
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Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine / Parlato, Rosanna [VerfasserIn]; 29 March 2010 (Online-Ressource)
