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| Verfasst von: | Kämmerer, Peer Wolfgang [VerfasserIn]  |
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| | Tribius, Silke [VerfasserIn] |
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| | Cohrs, Lena [VerfasserIn] |
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| | Engler, Gabriel [VerfasserIn] |
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| | Ettl, Tobias [VerfasserIn] |
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| | Freier, Kolja [VerfasserIn] |
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| | Frerich, Bernhard [VerfasserIn] |
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| | Ghanaati, Shahram [VerfasserIn] |
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| | Gosau, Martin [VerfasserIn] |
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| | Haim, Dominik [VerfasserIn] |
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| | Hartmann, Stefan [VerfasserIn] |
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| | Heiland, Max [VerfasserIn] |
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| | Herbst, Manuel [VerfasserIn] |
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| | Hoefert, Sebastian [VerfasserIn] |
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| | Hoffmann, Jürgen [VerfasserIn] |
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| | Hölzle, Frank [VerfasserIn] |
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| | Howaldt, Hans-Peter [VerfasserIn] |
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| | Kreutzer, Kilian [VerfasserIn] |
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| | Leonhardt, Henry [VerfasserIn] |
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| | Lutz, Rainer [VerfasserIn] |
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| | Moergel, Maximilian [VerfasserIn] |
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| | Modabber, Ali [VerfasserIn] |
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| | Neff, Andreas [VerfasserIn] |
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| | Pietzka, Sebastian [VerfasserIn] |
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| | Rau, Andrea [VerfasserIn] |
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| | Reichert, Torsten E. [VerfasserIn] |
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| | Smeets, Ralf [VerfasserIn] |
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| | Sproll, Christoph [VerfasserIn] |
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| | Steller, Daniel [VerfasserIn] |
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| | Wiltfang, Jörg [VerfasserIn] |
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| | Wolff, Klaus-Dietrich [VerfasserIn] |
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| | Kronfeld, Kai [VerfasserIn] |
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| | Al-Nawas, Bilal [VerfasserIn] |
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| Titel: | Adjuvant radiotherapy in patients with squamous cell carcinoma of the oral cavity or oropharynx and solitary ipsilateral lymph node metastasis (pN1) - a prospective multicentric cohort study |
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| Verf.angabe: | Peer W. Kämmerer, Silke Tribius, Lena Cohrs, Gabriel Engler, Tobias Ettl, Kolja Freier, Bernhard Frerich, Shahram Ghanaati, Martin Gosau, Dominik Haim, Stefan Hartmann, Max Heiland, Manuel Herbst, Sebastian Hoefert, Jürgen Hoffmann, Frank Hölzle, Hans-Peter Howaldt, Kilian Kreutzer, Henry Leonhardt, Rainer Lutz, Maximilian Moergel, Ali Modabber, Andreas Neff, Sebastian Pietzka, Andrea Rau, Torsten E. Reichert, Ralf Smeets, Christoph Sproll, Daniel Steller, Jörg Wiltfang, Klaus-Dietrich Wolff, Kai Kronfeld and Bilal Al-Nawas |
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| E-Jahr: | 2023 |
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| Jahr: | 18 March 2023 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 26.06.2023 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 15(2023), 6 vom: März, Artikel-ID 1833, Seite 1-13 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | (1) Background: Evaluation of impact of adjuvant radiation therapy (RT) in patients with oral squamous cell carcinoma of the oral cavity/oropharynx (OSCC) of up to 4 cm (pT1/pT2) and solitary ipsilateral lymph node metastasis (pN1). A non-irradiated group with clinical follow-up was chosen for control, and survival and quality of life (QL) were compared; (2) Methods: This prospective multicentric comprehensive cohort study included patients with resected OSCC (pT1/pT2, pN1, and cM0) who were allocated into adjuvant radiation therapy (RT) or observation. The primary endpoint was overall survival. Secondary endpoints were progression-free survival and QL after surgery; (3) Results: Out of 27 centers, 209 patients were enrolled with a median follow-up of 3.4 years. An amount of 137 patients were in the observation arm, and 72 received adjuvant irradiation. Overall survival did not differ between groups (hazard ratio (HR) 0.98 [0.55-1.73], p = 0.94). There were fewer neck metastases (HR 0.34 [0.15-0.77]; p = 0.01), as well as fewer local recurrences (HR 0.41 [0.19-0.89]; p = 0.02) under adjuvant RT. For QL, irradiated patients showed higher values for the symptom scale pain after 0.5, two, and three years (all p < 0.05). After six months and three years, irradiated patients reported higher symptom burdens (impaired swallowing, speech, as well as teeth-related problems (all p < 0.05)). Patients in the RT group had significantly more problems with mouth opening after six months, one, and two years (p < 0.05); (4) Conclusions: Adjuvant RT in patients with early SCC of the oral cavity and oropharynx does not seem to influence overall survival, but it positively affects progression-free survival. However, irradiated patients report a significantly decreased QL up to three years after therapy compared to the observation group. |
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| DOI: | doi:10.3390/cancers15061833 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers15061833 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/15/6/1833 |
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| | DOI: https://doi.org/10.3390/cancers15061833 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | lymph node |
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| | multicentric |
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| | oral squamous cell carcinoma |
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| | oropharyngeal carcinoma |
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| | pN1 |
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| | progression-free survival |
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| | prospective |
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| | quality of life |
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| | radiotherapy |
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| | resection |
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| | surgery |
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| | survival |
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| K10plus-PPN: | 1850977445 |
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| Verknüpfungen: | → Zeitschrift |
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Adjuvant radiotherapy in patients with squamous cell carcinoma of the oral cavity or oropharynx and solitary ipsilateral lymph node metastasis (pN1) - a prospective multicentric cohort study / Kämmerer, Peer Wolfgang [VerfasserIn]; 18 March 2023 (Online-Ressource)
