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Verfasst von:Schupp, Tobias [VerfasserIn]   i
 Müller, Julian [VerfasserIn]   i
 Zworowsky, Max von [VerfasserIn]   i
 Abumayyaleh, Mohammad S. A. [VerfasserIn]   i
 Weidner, Kathrin [VerfasserIn]   i
 Rusnak, Jonas [VerfasserIn]   i
 Mashayekhi, Kambis [VerfasserIn]   i
 Bertsch, Thomas [VerfasserIn]   i
 Akın, Ibrahim [VerfasserIn]   i
 Behnes, Michael [VerfasserIn]   i
Titel:Digitalis therapy in patients with ventricular tachyarrhythmias
Verf.angabe:Tobias Schupp, Julian Müller, Max von Zworowsky, Mohammad Abumayyaleh, Kathrin Weidner, Jonas Rusnak, Kambis Mashayekhi, Thomas Bertsch, Ibrahim Akin and Michael Behnes
E-Jahr:2022
Jahr:06 Jul 2022
Umfang:10 S.
Fussnoten:Gesehen am 26.06.2023
Titel Quelle:Enthalten in: Scandinavian cardiovascular journal
Ort Quelle:Abingdon : Taylor & Francis Group, 1997
Jahr Quelle:2022
Band/Heft Quelle:56(2022), 1, Seite 198-207
ISSN Quelle:1651-2006
Abstract:Objective. The study sought to assess the prognostic value of treatment with digitalis on long-term prognosis in patients with ventricular tachyarrhythmias and atrial fibrillation (AF) and/or heart failure (HF). Background. Data regarding the outcome of digitalis therapy following ventricular tachyarrhythmias is limited. Methods. A large retrospective registry was used including consecutive patients with episodes of ventricular tachycardia (VT) or fibrillation (VF) from 2002 to 2015. Patients treated with digitalis were compared to patients without. The primary prognostic endpoint was all-cause mortality at 3 years, secondary endpoints comprised a composite arrhythmic endpoint (i.e. recurrences of ventricular tachyarrhythmias, appropriate implantable cardioverter defibrillator (ICD) therapies, sudden cardiac death) and cardiac rehospitalization. Kaplan Mayer survival curves, multivariable cox regression, and time trend analyses were applied for statistics. Results. Eight hundred and thirty-one patients were included (20% treated with digitalis and 80% without). At 3 years, digitalis treatment was not associated with all-cause mortality following ventricular tachyarrhythmias (24 vs. 21%, log-rank p = .736; HR = 1.063; 95% CI 0.746-1.515; p = .736). However, digitalis therapy was associated with an increased risk of the composite arrhythmic endpoint (38 vs. 23%; log-rank p = .001; HR = 1.719; 95% CI 1.279-2.311; p = .001) and cardiac rehospitalization (31 vs. 18%; log-rank p = .001; HR = 1.829; 95% CI 1.318-2.538; p = .001), which was still evident within multivariable Cox regression analyses. Finally, digitoxin may be associated with a worse prognosis than digoxin. Conclusion. Digitalis therapy was not associated with mortality in patients with ventricular tachyarrhythmias, but with increased risk of the composite arrhythmic endpoint and cardiac rehospitalization at 3 years.
DOI:doi:10.1080/14017431.2022.2091793
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1080/14017431.2022.2091793
 kostenfrei: Volltext: https://doi.org/10.1080/14017431.2022.2091793
 DOI: https://doi.org/10.1080/14017431.2022.2091793
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:atrial fibrillation
 digitalis
 heart failure
 medical treatment
 mortality
 pharmacological drugs
 ventricular fibrillation
 Ventricular tachycardia
K10plus-PPN:1850986363
Verknüpfungen:→ Zeitschrift

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