Navigation überspringen
Universitätsbibliothek Heidelberg
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Yazdani, Babak [VerfasserIn]   i
 Delgado Gonzales de Kleber, Graciela [VerfasserIn]   i
 Kleber, Marcus E. [VerfasserIn]   i
 Yücel, Gökhan [VerfasserIn]   i
 Husain-Syed, Faeq [VerfasserIn]   i
 Kraemer, Thomas D. [VerfasserIn]   i
 Jochims, Jan Alexander [VerfasserIn]   i
 Leipe, Jan [VerfasserIn]   i
 März, Winfried [VerfasserIn]   i
 Krämer, Bernhard [VerfasserIn]   i
Titel:The renin-angiotensin-aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC
Verf.angabe:Babak Yazdani, Graciela E. Delgado, Marcus E. Kleber, Gökhan Yücel, Faeq Husain-Syed, Thomas D. Kraemer, Jan Jochims, Jan Leipe, Winfried März, Bernhard K. Krämer
E-Jahr:2022
Jahr:09 November 2022
Umfang:11 S.
Fussnoten:Gesehen am 27.06.2023
Titel Quelle:Enthalten in: The journal of clinical hypertension
Ort Quelle:Hoboken, NJ : Wiley, 2001
Jahr Quelle:2022
Band/Heft Quelle:24(2022), 12 vom: Dez., Seite 1587-1597
ISSN Quelle:1751-7176
Abstract:Although neurohormones and Renin-Angiotensin-Aldosterone-System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS-blockers and different degrees of arterial stiffness is less understood. We therefore analyzed long-term data from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study in 3316 patients subdivided according to pulse pressure (PP) and RAAS-blocker use. Patients on RAAS-inhibition had higher renin and noradrenaline, lower aldosterone and aldosterone/renin quotient (ARQ). Renin and noradrenaline significantly predicted CVM in patients without RAAS-blocker (HR = 1.17, 1.15) and in patients receiving angiotensin-converting-enzyme (ACE) inhibitors (HR = 1.17, 1.29), whereas aldosterone predicted CVM only in patients receiving ACE-inhibitors (HR = 1.13). CVM was predicted independently from PP by renin, noradrenaline and angiotensin II. Independently from RAAS inhibition renin decreased and ARQs increased with rising PP. Furthermore, noradrenaline increased with PP, but only without ACE-inhibition. The HR for CVM in the ACE-inhibitor group were 1.29, 1.28, 1.29 for renin in the first, second and third PP quartiles and 1.22, and 1.19 for aldosterone in the second and fourth quartile. Furthermore, we showed that noradrenaline predicts CVM in all PP quartiles in patients with ACE-inhibition. In the RAAS-blocker-free group, the HR for renin for CVM were 1.36 and 1.18 in the third and fourth PP quartiles, but neither aldosterone nor noradrenaline were predictive for CVM within the PP quartiles. Renin and noradrenaline are strong predictors of CVM regardless of RAAS blockade, whereas aldosterone is predictive only in the ACE-inhibitor group. Catecholamines but not renin are associated with rising PP.
DOI:doi:10.1111/jch.14593
URL:kostenfrei: Volltext: https://doi.org/10.1111/jch.14593
 kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/jch.14593
 DOI: https://doi.org/10.1111/jch.14593
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ACE-inhibitors
 arterial compliance
 atherosclerosis
 cardiovascular mortality
 noradrenaline
 pulse pressure
K10plus-PPN:1851054596
Verknüpfungen:→ Zeitschrift
 
 
Lokale URL UB: Zum Volltext

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69090177   QR-Code
zum Seitenanfang