| |  Online-Ressource |
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| Verfasst von: | Garg, Niharika [VerfasserIn]  |
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| | Stibler, Urska [VerfasserIn] |
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| | Eismann, Björn [VerfasserIn] |
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| | Mercker, Moritz [VerfasserIn] |
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| | Bergheim, Bruno Gideon [VerfasserIn] |
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| | Linn, Anna [VerfasserIn] |
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| | Tuchscherer, Patrizia [VerfasserIn] |
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| | Engel, Ulrike [VerfasserIn] |
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| | Redl, Stefan [VerfasserIn] |
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| | Marciniak-Czochra, Anna [VerfasserIn] |
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| | Holstein, Thomas W. [VerfasserIn] |
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| | Hess, Michael W. [VerfasserIn] |
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| | Özbek, Suat [VerfasserIn] |
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| Titel: | Non-muscle myosin II drives critical steps of nematocyst morphogenesis |
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| Verf.angabe: | Niharika Garg, Urška Knez Štibler, Björn Eismann, Moritz Mercker, Bruno Gideon Bergheim, Anna Linn, Patrizia Tuchscherer, Ulrike Engel, Stefan Redl, Anna Marciniak-Czochra, Thomas W. Holstein, Michael W. Hess, and Suat Özbek |
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| E-Jahr: | 2023 |
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| Jahr: | 9 March 2023 |
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| Umfang: | 26 S. |
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| Fussnoten: | Online verfügbar 28. Februar 2023, Artikelversion 9. März 2023 ; Gesehen am 03.07.2023 |
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| Titel Quelle: | Enthalten in: iScience |
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| Ort Quelle: | Amsterdam : Elsevier, 2018 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 26(2023), 3 vom: März, Artikel-ID 106291, Seite 1-26 |
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| ISSN Quelle: | 2589-0042 |
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| Abstract: | Nematocysts are generated by secretion of proteins into a post-Golgi compartment. They consist of a capsule that elongates into a long tube, which is coiled inside the capsule matrix and expelled during its nano-second discharge deployed for prey capture. The driving force for discharge is an extreme osmotic pressure of 150 bar. The complex processes of tube elongation and invagination under these biomechanical constraints have so far been elusive. Here, we show that a non-muscle myosin II homolog (HyNMII) is essential for nematocyst formation in Hydra. In early nematocysts, HyNMII assembles to a collar around the neck of the protruding tube. HyNMII then facilitates tube outgrowth by compressing it along the longitudinal axis as evidenced by inhibitor treatment and genetic knockdown. In addition, live imaging of a NOWA::NOWA-GFP transgenic line, which re-defined NOWA as a tube component facilitating invagination, allowed us to analyze the impact of HyNMII on tube maturation. |
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| DOI: | doi:10.1016/j.isci.2023.106291 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.isci.2023.106291 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2589004223003681 |
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| | DOI: https://doi.org/10.1016/j.isci.2023.106291 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cell biology |
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| | Developmental biology |
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| K10plus-PPN: | 1851424466 |
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| Verknüpfungen: | → Zeitschrift |
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Non-muscle myosin II drives critical steps of nematocyst morphogenesis / Garg, Niharika [VerfasserIn]; 9 March 2023 (Online-Ressource)
