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| Verfasst von: | Ansari, Uzair [VerfasserIn]  |
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| | Overhoff, Daniel [VerfasserIn] |
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| | Burkhoff, Daniel [VerfasserIn] |
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| | Fastner, Christian [VerfasserIn] |
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| | Yücel, Gökhan [VerfasserIn] |
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| | Röger, Susanne [VerfasserIn] |
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| | Rudic, Boris [VerfasserIn] |
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| | Liebe, Volker [VerfasserIn] |
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| | Borggrefe, Martin [VerfasserIn] |
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| | Akın, Ibrahim [VerfasserIn] |
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| | Kuschyk, Jürgen [VerfasserIn] |
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| | Papavassiliu, Theano [VerfasserIn] |
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| | Tueluemen, Erol [VerfasserIn] |
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| Titel: | Septal myocardial scar burden predicts the response to cardiac contractility modulation in patients with heart failure |
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| Verf.angabe: | Uzair Ansari, Daniel Overhoff, Daniel Burkhoff, Christian Fastner, Gökhan Yücel, Susanne Röger, Boris Rudic, Volker Liebe, Martin Borggrefe, Ibrahim Akin, Jürgen Kuschyk, Theano Papavassiliu and Erol Tülümen |
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| E-Jahr: | 2022 |
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| Jahr: | 28 November 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 03.07.2023 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 12(2022), Artikel-ID 20504, Seite 1-10 |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | We hypothesized that myocardial septal scarring, assessed by cardiac magnetic resonance (CMR) using late gadolinium enhancement (LGE), at the site of cardiac contractility modulation (CCM) lead placement may predict treatment response. Eligible heart failure (HF) patients underwent LGE CMR imaging before CCM device implantation. The response to CCM therapy at follow-up was determined by a change in NYHA class and echocardiographic left ventricular ejection fraction (LVEF) assessment. Patients were classified as responders, if they showed an improvement in either NYHA class or improvement of LVEF by ≥ 5%. 58 patients were included. 67% of patients were classified as responders according to improved NYHA; 55% according to LVEF improvement. 74% of patients were responders if either NYHA class or LVEF improvement was observed. 90% of responders (according to NYHA class) showed septal LGE < 25% at septal position of the leads, while 44% of non-responders showed septal LGE > 25% (p < 0.01). In patients treated with CCM, an improvement of NYHA class was observed when leads were placed at myocardial segments with a CMR- LGE burden less than 25%. |
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| DOI: | doi:10.1038/s41598-022-24461-6 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1038/s41598-022-24461-6 |
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| | kostenfrei: Volltext: http://www.nature.com/articles/s41598-022-24461-6 |
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| | DOI: https://doi.org/10.1038/s41598-022-24461-6 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cardiac device therapy |
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| | Cardiology |
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| K10plus-PPN: | 1851424539 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Septal myocardial scar burden predicts the response to cardiac contractility modulation in patients with heart failure / Ansari, Uzair [VerfasserIn]; 28 November 2022 (Online-Ressource)
