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Verfasst von:Luft, Thomas [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
 Radujković, Aleksandar [VerfasserIn]   i
Titel:Endothelial cell dysfunction
Titelzusatz:a key determinant for the outcome of allogeneic stem cell transplantation
Verf.angabe:Thomas Luft, Peter Dreger & Aleksandar Radujkovic
E-Jahr:2021
Jahr:12 July 2021
Umfang:10 S.
Fussnoten:Gesehen am 03.07.2023
Titel Quelle:Enthalten in: Bone marrow transplantation
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2021
Band/Heft Quelle:56(2021), 10, Seite 2326-2335
ISSN Quelle:1476-5365
Abstract:Abstract - Allogeneic hematopoietic stem cell transplantation (alloSCT) carries the promise of cure for many malignant and non-malignant diseases of the lympho-hematopoietic system. Although outcome has improved considerably since the pioneering Seattle achievements more than 5 decades ago, non-relapse mortality (NRM) remains a major burden of alloSCT. There is increasing evidence that endothelial dysfunction is involved in many of the life-threatening complications of alloSCT, such as sinusoidal obstruction syndrome/venoocclusive disease, transplant-associated thrombotic microangiopathy, and refractory acute graft-versus host disease. This review delineates the role of the endothelium in severe complications after alloSCT and describes the current status of search for biomarkers predicting endothelial complications, including markers of endothelial vulnerability and markers of endothelial injury. Finally, implications of our current understanding of transplant-associated endothelial pathology for prevention and management of complications after alloSCT are discussed.
DOI:doi:10.1038/s41409-021-01390-y
URL:kostenfrei: Volltext: https://doi.org/10.1038/s41409-021-01390-y
 kostenfrei: Volltext: https://www.nature.com/articles/s41409-021-01390-y
 DOI: https://doi.org/10.1038/s41409-021-01390-y
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1851476261
Verknüpfungen:→ Zeitschrift
 
 
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