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Status: Bibliographieeintrag

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Verfasst von:Martín-Cortecero, Jesús [VerfasserIn]   i
 Isaías-Camacho, Emilio Ulises [VerfasserIn]   i
 Boztepe, Berin [VerfasserIn]   i
 Ziegler, Katharina [VerfasserIn]   i
 Mease, Rebecca A. [VerfasserIn]   i
 Groh, Alexander [VerfasserIn]   i
Titel:Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals
Verf.angabe:Jesús Martín-Cortecero, Emilio Ulises Isaías-Camacho, Berin Boztepe, Katharina Ziegler, Rebecca Audrey Mease, Alexander Groh
E-Jahr:2023
Jahr:May 19, 2023
Umfang:29 S.
Fussnoten:Gesehen am 07.07.2023
Titel Quelle:Enthalten in: Public Library of SciencePLoS biology
Ort Quelle:Lawrence, KS : PLoS, 2003
Jahr Quelle:2023
Band/Heft Quelle:21(2023), 5 vom: Mai, Artikel-ID e3002126, Seite 1-29
ISSN Quelle:1545-7885
Abstract:The superior colliculus (SC), a conserved midbrain node with extensive long-range connectivity throughout the brain, is a key structure for innate behaviors. Descending cortical pathways are increasingly recognized as central control points for SC-mediated behaviors, but how cortico-collicular pathways coordinate SC activity at the cellular level is poorly understood. Moreover, despite the known role of the SC as a multisensory integrator, the involvement of the SC in the somatosensory system is largely unexplored in comparison to its involvement in the visual and auditory systems. Here, we mapped the connectivity of the whisker-sensitive region of the SC in mice with trans-synaptic and intersectional tracing tools and in vivo electrophysiology. The results reveal a novel trans-collicular connectivity motif in which neurons in motor- and somatosensory cortices impinge onto the brainstem-SC-brainstem sensory-motor arc and onto SC-midbrain output pathways via only one synapse in the SC. Intersectional approaches and optogenetically assisted connectivity quantifications in vivo reveal convergence of motor and somatosensory cortical input on individual SC neurons, providing a new framework for sensory-motor integration in the SC. More than a third of the cortical recipient neurons in the whisker SC are GABAergic neurons, which include a hitherto unknown population of GABAergic projection neurons targeting thalamic nuclei and the zona incerta. These results pinpoint a whisker region in the SC of mice as a node for the integration of somatosensory and motor cortical signals via parallel excitatory and inhibitory trans-collicular pathways, which link cortical and subcortical whisker circuits for somato-motor integration.
DOI:doi:10.1371/journal.pbio.3002126
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1371/journal.pbio.3002126
 Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002126
 DOI: https://doi.org/10.1371/journal.pbio.3002126
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Axons
 Brainstem
 Cerebellar nuclei
 Fluorescence imaging
 Motor neurons
 Neurons
 Sensory perception
 Vibrissae
K10plus-PPN:1852134062
Verknüpfungen:→ Zeitschrift

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