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| Verfasst von: | Magallón-Lorenz, Míriam [VerfasserIn]  |
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| | Terribas, Ernest [VerfasserIn] |
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| | Ortega-Bertran, Sara [VerfasserIn] |
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| | Creus-Bachiller, Edgar [VerfasserIn] |
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| | Fernández, Marco [VerfasserIn] |
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| | Requena, Gerard [VerfasserIn] |
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| | Rosas, Inma [VerfasserIn] |
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| | Mazuelas, Helena [VerfasserIn] |
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| | Uriarte-Arrazola, Itziar [VerfasserIn] |
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| | Negro, Alex [VerfasserIn] |
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| | Lausová, Tereza [VerfasserIn] |
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| | Castellanos, Elisabeth [VerfasserIn] |
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| | Blanco, Ignacio [VerfasserIn] |
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| | DeVries, George [VerfasserIn] |
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| | Kawashima, Hiroyuki [VerfasserIn] |
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| | Legius, Eric [VerfasserIn] |
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| | Brems, Hilde [VerfasserIn] |
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| | Mautner, Viktor [VerfasserIn] |
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| | Kluwe, Lan [VerfasserIn] |
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| | Ratner, Nancy [VerfasserIn] |
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| | Wallace, Margaret [VerfasserIn] |
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| | Fernández-Rodriguez, Juana [VerfasserIn] |
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| | Lázaro, Conxi [VerfasserIn] |
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| | Fletcher, Jonathan A. [VerfasserIn] |
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| | Reuss, David [VerfasserIn] |
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| | Carrió, Meritxell [VerfasserIn] |
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| | Gel, Bernat [VerfasserIn] |
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| | Serra, Eduard [VerfasserIn] |
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| Titel: | Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis |
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| Verf.angabe: | Miriam Magallón-Lorenz, Ernest Terribas, Sara Ortega-Bertran, Edgar Creus-Bachiller, Marco Fernández, Gerard Requena, Inma Rosas, Helena Mazuelas, Itziar Uriarte-Arrazola, Alex Negro, Tereza Lausová, Elisabeth Castellanos, Ignacio Blanco, George DeVries, Hiroyuki Kawashima, Eric Legius, Hilde Brems, Viktor Mautner, Lan Kluwe, Nancy Ratner, Margaret Wallace, Juana Fernández-Rodriguez, Conxi Lázaro, Jonathan A. Fletcher, David Reuss, Meritxell Carrió, Bernat Gel, and Eduard Serra |
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| E-Jahr: | 2023 |
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| Jahr: | 9 February 2023 |
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| Umfang: | 23 S. |
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| Fussnoten: | Online verfügbar 31. Januar 2023, Artikelversion 9. Februar 2023 ; Gesehen am 10.07.2023 |
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| Titel Quelle: | Enthalten in: iScience |
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| Ort Quelle: | Amsterdam : Elsevier, 2018 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 26(2023), 2 vom: Feb., Artikel-ID 106096, Seite 1-23 |
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| ISSN Quelle: | 2589-0042 |
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| Abstract: | Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas of the peripheral nervous system that develop either sporadically or in the context of neurofibromatosis type 1 (NF1). MPNST diagnosis can be challenging and treatment outcomes are poor. We present here a resource consisting of the genomic characterization of 9 widely used human MPNST cell lines for their use in translational research. NF1-related cell lines recapitulated primary MPNST copy number profiles, exhibited NF1, CDKN2A, and SUZ12/EED tumor suppressor gene (TSG) inactivation, and presented no gain-of-function mutations. In contrast, sporadic cell lines collectively displayed different TSG inactivation patterns and presented kinase-activating mutations, fusion genes, altered mutational frequencies and COSMIC signatures, and different methylome-based classifications. Cell lines re-classified as melanomas and other sarcomas exhibited a different drug-treatment response. Deep genomic analysis, methylome-based classification, and cell-identity marker expression, challenged the identity of common MPNST cell lines, opening an opportunity to revise MPNST differential diagnosis. |
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| DOI: | doi:10.1016/j.isci.2023.106096 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.isci.2023.106096 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2589004223001736 |
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| | DOI: https://doi.org/10.1016/j.isci.2023.106096 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Biological sciences |
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| | Cancer |
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| | Neuroscience |
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| | Omics |
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| K10plus-PPN: | 1852258284 |
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| Verknüpfungen: | → Zeitschrift |
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Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis / Magallón-Lorenz, Míriam [VerfasserIn]; 9 February 2023 (Online-Ressource)
