25(OH)D-but not 1,25(OH)2D-is an independent risk factor predicting graft loss in stable kidney transplant recipients

• Verfasst von: Zeng, Shufei [VerfasserIn]
• Verfasst von: Yang, Yide [VerfasserIn]
• Verfasst von: Li, Shuping [VerfasserIn]
• Verfasst von: Hocher, Carl-Friedrich [VerfasserIn]
• Verfasst von: Chu, Chang [VerfasserIn]
• Verfasst von: Wang, Ziqiang [VerfasserIn]
• Verfasst von: Zheng, Zhihua [VerfasserIn]
• Verfasst von: Krämer, Bernhard [VerfasserIn]
• Verfasst von: Hocher, Berthold [VerfasserIn]
• Titel: 25(OH)D-but not 1,25(OH)2D-is an independent risk factor predicting graft loss in stable kidney transplant recipients
• Verf.angabe: Shufei Zeng, Yide Yang, Shuping Li, Carl-Friedrich Hocher, Chang Chu, Ziqiang Wang, Zhihua Zheng, Bernhard K. Krämer and Berthold Hocher
• E-Jahr: 2023
• Jahr: 20 April 2023
• Umfang: 10 S.
• Fussnoten: Gesehen am 10.07.2023
• Titel Quelle: Enthalten in: Frontiers in medicine
• Ort Quelle: Lausanne : Frontiers Media, 2014
• Jahr Quelle: 2023
• Band/Heft Quelle: 10(2023) vom: Apr., Artikel-ID 1141646, Seite 1-10
• ISSN Quelle: 2296-858X
• DOI: doi:10.3389/fmed.2023.1141646
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1852261773
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

BackgroundVitamin D deficiency (VDD) or vitamin D insufficiency is common in kidney transplant recipients (KTRs). The impact of VDD on clinical outcomes in KTRs remain poorly defined and the most suitable marker for assessing vitamin D nutritional status in KTRs is unknown so far.MethodsWe conducted a prospective study including 600 stable KTRs (367 men, 233 women) and a meta-analysis to pool existing evidence to determine whether 25(OH)D or 1,25(OH)2D predicted graft failure and all-cause mortality in stable KTRs.ResultsCompared with a higher 25(OH)D concentration, a low concentration of 25(OH)D was a risk factor for graft failure (HR 0.946, 95% CI 0.912−0.981, p = 0.003), whereas 1,25 (OH)2D was not associated with the study end-point graft loss (HR 0.993, 95% CI 0.977−1.009, p = 0.402). No association was found between either 25(OH)D or 1,25 (OH)2D and all-cause mortality. We furthermore conducted a meta-analysis including 8 studies regarding the association between 25(OH)D or 1,25(OH)2D and graft failure or mortality, including our study. The meta-analysis results were consistent with our study in finding that lower 25(OH)D levels were significantly associated with the risk of graft failure (OR = 1.04, 95% CI: 1.01−1.07), but not associated with mortality (OR = 1.00, 95% CI: 0.98−1.03). Lower 1,25(OH)2D levels were not associated with the risk of graft failure (OR = 1.01, 95% CI: 0.99−1.02) and mortality (OR = 1.01, 95% CI: 0.99−1.02).ConclusionBaseline 25(OH)D concentrations but not 1,25(OH)2D concentrations were independently and inversely associated with graft loss in adult KTRs.