| |  Online-Ressource |
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| Verfasst von: | Mussetti, Alberto [VerfasserIn]  |
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| | Kanate, Abraham S. [VerfasserIn] |
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| | Wang, Tao [VerfasserIn] |
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| | He, Meilun [VerfasserIn] |
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| | Hamadani, Mehdi [VerfasserIn] |
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| | Finel, Hervé [VerfasserIn] |
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| | Boumendil, Ariane [VerfasserIn] |
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| | Glass, Bertram [VerfasserIn] |
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| | Castagna, Luca [VerfasserIn] |
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| | Dominietto, Alida [VerfasserIn] |
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| | McGuirk, Joseph [VerfasserIn] |
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| | Blaise, Didier [VerfasserIn] |
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| | Gülbas, Zafer [VerfasserIn] |
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| | Diez-Martin, Jose [VerfasserIn] |
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| | Marsh, Steven G. E. [VerfasserIn] |
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| | Paczesny, Sophie [VerfasserIn] |
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| | Gadalla, Shahinaz M. [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Zhang, Mei-Jie [VerfasserIn] |
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| | Spellman, Stephen R. [VerfasserIn] |
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| | Lee, Stephanie J. [VerfasserIn] |
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| | Bolon, Yung-Tsi [VerfasserIn] |
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| | Sureda, Anna [VerfasserIn] |
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| Titel: | Haploidentical versus matched unrelated donor transplants using post-transplantation cyclophosphamide for lymphomas |
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| Verf.angabe: | Alberto Mussetti, Abraham S. Kanate, Tao Wang, Meilun He, Mehdi Hamadani, Hervé Finel, Ariane Boumendil, Bertram Glass, Luca Castagna, Alida Dominietto, Joseph McGuirk, Didier Blaise, Zafer Gülbas, Jose Diez-Martin, Steven G. E. Marsh, Sophie Paczesny, Shahinaz M. Gadalla, Peter Dreger, Mei-Jie Zhang, Stephen R. Spellman, Stephanie J. Lee, Yung-Tsi Bolon, Anna Sureda |
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| E-Jahr: | 2023 |
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| Jahr: | 28 February 2023 |
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| Umfang: | 9 S. |
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| Fussnoten: | Online verfügbar 25. Dezember 2022, Artikelversion 28. Februar 2023 ; Gesehen am 11.07.2023 |
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| Titel Quelle: | Enthalten in: Transplantation and cellular therapy |
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| Ort Quelle: | [Amsterdam] : Elsevier B. V., 2021 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 29(2023), 3 vom: Feb., Seite 184.e1-184.e9 |
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| ISSN Quelle: | 2666-6367 |
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| Abstract: | When using post-transplantation cyclophosphamide (PTCy) graft-versus-host disease (GVHD) prophylaxis for lymphoma patients, it is currently unknown whether a matched unrelated donor (MUD) or a haploidentical related donor is preferable if both are available. In this study we wanted to test whether using a haploidentical donor has the same results of a MUD. A total of 2140 adults (34% Center for International Blood and Marrow Transplant Research, 66% European Society for Blood and Marrow Transplantation registry) aged ≥18 years who received their first haploidentical hematopoietic cell transplantation (haplo-HCT) or MUD-HCT (8/8 match at HLA-loci A, B, C, and DRB1) for lymphoma using PTCy-based GVHD prophylaxis from 2010 to 2019 were retrospectively analyzed. The majority of both MUD and haploidentical HCTs received reduced intensity/nonmyeloablative conditioning (74% and 77%, respectively) and used a peripheral blood stem cell graft (91% and 60%, respectively) and a 3-drug GVHD prophylaxis (PTCy + calcineurin inhibitor + MMF in 54% and 90%, respectively). Haploidentical HCT has less favorable results versus MUD cohort in terms of overall mortality (hazard ratio [HR= = 1.69; 95% confidence interval [CI], 1.30-2.27; P < .001), progression-free survival (HR=1.39; 95% CI, 1.10-1.79; P = .008), nonrelapse mortality (HR = 1.93; 95% CI, 1.21-3.07; P = .006), platelet engraftment (HR = 0.69; 95% CI, 0.59-0.80; P < .001), acute grade 2-4 GVHD incidence (HR = 1.65; 95% CI, 1.28-2.14; P < .001), and chronic GVHD (HR = 1.79; 95% CI, 1.30-2.48, P < .001). No significant differences were observed in terms of relapse and neutrophil engraftment. Adjusting for propensity score yielded similar results. Whenever MUD is available in a timely manner, it should be preferred over a haploidentical donor when using PTCy-based GVHD prophylaxis for patients with lymphoma. |
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| DOI: | doi:10.1016/j.jtct.2022.11.028 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jtct.2022.11.028 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2666636722018012 |
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| | DOI: https://doi.org/10.1016/j.jtct.2022.11.028 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Haploidentical donor |
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| | Lymphoma |
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| | Matched unrelated donor |
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| | Post-transplant cyclophosphamide |
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| K10plus-PPN: | 1852358416 |
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| Verknüpfungen: | → Zeitschrift |
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Haploidentical versus matched unrelated donor transplants using post-transplantation cyclophosphamide for lymphomas / Mussetti, Alberto [VerfasserIn]; 28 February 2023 (Online-Ressource)
