Direct and indirect vaccination effects on SARS-CoV-2 infection in day-care centres

• Verfasst von: Schoeps, Anja [VerfasserIn]
• Verfasst von: Walter, Jan [VerfasserIn]
• Verfasst von: Vogt, Manfred [VerfasserIn]
• Verfasst von: Bent, Stefan [VerfasserIn]
• Verfasst von: Zanger, Philipp [VerfasserIn]
• Titel: Direct and indirect vaccination effects on SARS-CoV-2 infection in day-care centres
• Titelzusatz: evaluating the policy for early vaccination of day-care staff in Germany, 2021
• Verf.angabe: Anja Schoeps, Jan Walter, Manfred Vogt, Stefan Bent, Philipp Zanger and the Palatina Public Health Study Group
• E-Jahr: 2023
• Jahr: 04 May 2023
• Umfang: 4 S.
• Fussnoten: Gesehen am 12.07.2023
• Titel Quelle: Enthalten in: Epidemiology and infection
• Ort Quelle: Cambridge [u.a.] : Cambridge Univ. Press, 1987
• Jahr Quelle: 2023
• Band/Heft Quelle: 151(2023), Artikel-ID e80, Seite 1-4
• ISSN Quelle: 1469-4409
• DOI: doi:10.1017/S0950268823000638
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Child Daycare Centers
• Sach-SW: Interrupted Time Series Analysis
• Sach-SW: SARS-CoV-2
• Sach-SW: Staff
• Sach-SW: Transmission
• Sach-SW: Vaccination
• K10plus-PPN: 1852470534
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

To mitigate the known high transmission risk in day-care facilities for children aged 0-6 years, day-care staff were given priority for SARS-CoV-2 vaccination in Rhineland-Palatinate, Germany, in March 2021. This study assessed direct and indirect effects of early vaccination of day-care staff on SARS-CoV-2 transmission in daycares with the aim to provide a basis for the prioritisation of scarce vaccines in the future. Data came from statutory infectious disease notifications in educational institutions and from in-depth investigations by the district public health authorities. Using interrupted time series analyses, we measured the effect of mRNA-based vaccination of day-care staff on SARS-CoV-2 infections and transmission. Among 566 index cases from day-care centres, the mean number of secondary SARS-CoV-2 infections per index case dropped by −0.60 case per month after March 2021. The proportion of staff among all cases reported from daycares was around 60% in the pre-interruption phase and significantly decreased by 27 percentage points immediately in March 2021 and by further 6 percentage points each month in the post-interruption phase. Early vaccination of day-care staff reduced SARS-CoV-2 cases in the overall day-care setting and thus also protected unvaccinated children. This should inform future decisions on vaccination prioritisation.