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| Verfasst von: | Wölber, Linn [VerfasserIn]  |
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| | Hampl, Monika [VerfasserIn] |
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| | Eulenburg, Christine Helene <Gräfin zu> [VerfasserIn] |
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| | Prieske, Katharina [VerfasserIn] |
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| | Hambrecht, Johanna [VerfasserIn] |
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| | Fürst, Sophie-Theresa [VerfasserIn] |
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| | Klapdor, Rüdiger [VerfasserIn] |
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| | Heublein, Sabine [VerfasserIn] |
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| | Gass, Paul [VerfasserIn] |
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| | Rohner, Annika [VerfasserIn] |
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| | Canzler, Ulrich [VerfasserIn] |
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| | Becker, Sven [VerfasserIn] |
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| | Bommert, Mareike Anna Katharina [VerfasserIn] |
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| | Bauerschlag, Dirk Olaf [VerfasserIn] |
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| | Denecke, Agnieszka [VerfasserIn] |
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| | Hanker, Lars [VerfasserIn] |
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| | Runnebaum, Ingo B. [VerfasserIn] |
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| | Forner, Dirk Michael [VerfasserIn] |
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| | Schochter, Fabienne [VerfasserIn] |
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| | Klar, Maximilian [VerfasserIn] |
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| | Schwab, Roxana Michaela [VerfasserIn] |
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| | Köpke, Melitta [VerfasserIn] |
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| | Kalder, Matthias [VerfasserIn] |
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| | Hantschmann, Peer [VerfasserIn] |
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| | Ratiu, Dominik Alexander [VerfasserIn] |
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| | Denschlag, Dominik [VerfasserIn] |
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| | Schroeder, Willibald [VerfasserIn] |
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| | Tuschy, Benjamin [VerfasserIn] |
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| | Baumann, Klaus [VerfasserIn] |
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| | Mustea, Alexander [VerfasserIn] |
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| | Soergel, Philipp [VerfasserIn] |
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| | Bronger, Holger [VerfasserIn] |
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| | Bauerschmitz, Gerd Johannes [VerfasserIn] |
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| | Kosse, Jens Fabian [VerfasserIn] |
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| | Koch, Martin C. [VerfasserIn] |
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| | Ignatov, Atanas [VerfasserIn] |
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| | Sehouli, Jalid [VerfasserIn] |
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| | Dannecker, Christian [VerfasserIn] |
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| | Mahner, Sven [VerfasserIn] |
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| | Jaeger, Anna [VerfasserIn] |
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| Titel: | Risk for pelvic metastasis and role of pelvic lymphadenectomy in node-positive vulvar cancer |
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| Titelzusatz: | results from the AGO-VOP.2 QS vulva study |
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| Verf.angabe: | Linn Woelber, Monika Hampl, Christine zu Eulenburg, Katharina Prieske, Johanna Hambrecht, Sophie Fuerst, Ruediger Klapdor, Sabine Heublein, Paul Gass, Annika Rohner, Ulrich Canzler, Sven Becker, Mareike Bommert, Dirk Bauerschlag, Agnieszka Denecke, Lars Hanker, Ingo Runnebaumn, Dirk M. Forner, Fabienne Schochter, Maximilian Klar, Roxana Schwab, Melitta Koepke, Matthias Kalder, Peer Hantschmann, Dominik Ratiu, Dominik Denschlag, Willibald Schroeder, Benjamin Tuschy, Klaus Baumann, Alexander Mustea, Philipp Soergel, Holger Bronger, Gerd Bauerschmitz, Jens Kosse, Martin C. Koch, Atanas Ignatov, Jalid Sehouli, Christian Dannecker, Sven Mahner and Anna Jaeger |
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| E-Jahr: | 2022 |
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| Jahr: | 14 January 2022 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 17.07.2023 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 14(2022), 2, Artikel-ID 418, Seite 1-14 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | The need for pelvic treatment in patients with node-positive vulvar cancer (VSCC) and the value of pelvic lymphadenectomy (LAE) as a staging procedure to plan adjuvant radiotherapy (RT) is controversial. In this retrospective, multicenter analysis, 306 patients with primary node-positive VSCC treated at 33 gynecologic oncology centers in Germany between 2017 and 2019 were analyzed. All patients received surgical staging of the groins; nodal status was as follows: 23.9% (73/306) pN1a, 23.5% (72/306) pN1b, 20.4% (62/306) pN2a/b, and 31.9% (97/306) pN2c/pN3. A total of 35.6% (109/306) received pelvic LAE; pelvic nodal involvement was observed in 18.5%. None of the patients with nodal status pN1a or pN1b and pelvic LAE showed pelvic nodal involvement. Taking only patients with nodal status ≥pN2a into account, the rate of pelvic involvement was 25%. In total, adjuvant RT was applied in 64.4% (197/306). Only half of the pelvic node-positive (N+) patients received adjuvant RT to the pelvis (50%, 10/20 patients); 41.9% (122/291 patients) experienced recurrent disease or died. In patients with histologically-confirmed pelvic metastases after LAE, distant recurrences were most frequently observed (7/20 recurrences). Conclusions: A relevant risk regarding pelvic nodal involvement was observed from nodal status pN2a and higher. Our data support the omission of pelvic treatment in patients with nodal status pN1a and pN1b. |
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| DOI: | doi:10.3390/cancers14020418 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers14020418 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/14/2/418 |
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| | DOI: https://doi.org/10.3390/cancers14020418 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | groin |
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| | pelvic lymphadenectomy |
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| | prognosis |
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| | radiotherapy |
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| | recurrence |
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| | vulvar cancer |
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| K10plus-PPN: | 1818594889 |
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| Verknüpfungen: | → Zeitschrift |
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Risk for pelvic metastasis and role of pelvic lymphadenectomy in node-positive vulvar cancer / Wölber, Linn [VerfasserIn]; 14 January 2022 (Online-Ressource)
