Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk

• Verfasst von: Galbraith, Rachel L. [VerfasserIn]
• Verfasst von: Poole, Elizabeth M. [VerfasserIn]
• Verfasst von: Duggan, David [VerfasserIn]
• Verfasst von: Muehling, Jill [VerfasserIn]
• Verfasst von: Hsu, Li [VerfasserIn]
• Verfasst von: Makar, Karen [VerfasserIn]
• Verfasst von: Xiao, Liren [VerfasserIn]
• Verfasst von: Potter, John D. [VerfasserIn]
• Verfasst von: Ulrich, Cornelia [VerfasserIn]
• Titel: Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk
• Verf.angabe: Rachel L. Galbraith, Elizabeth M. Poole, David Duggan, Jill Muehling, Li Hsu, Karen Makar, Liren Xiao, John D. Potter, and Cornelia M. Ulrich
• E-Jahr: 2011
• Jahr: 05 May 2011
• Umfang: 7 S.
• Fussnoten: Gesehen am 13.07.2023 ; Veröffentlicht in der endgültigen redaktionellen Form ; Angabe zum PDF: Autorenmanuskript: verfügbar in PMC 2015 Mai 13, 13 Seiten
• Titel Quelle: Enthalten in: Nutrition and cancer
• Ort Quelle: New York, NY : Routledge, Taylor & Francis Group, 1978
• Jahr Quelle: 2011
• Band/Heft Quelle: 63(2011), 4, Seite 558-564
• ISSN Quelle: 1532-7914
• DOI: doi:10.1080/01635581.2011.542539
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1852585587

Abstract

The WNT/β-catenin signaling pathway upregulates transcription of genes involved in cell proliferation and cancer progression; it has been implicated in colorectal adenoma formation. To date, no studies have examined polymorphisms in WNT genes or WNT gene-environment interactions in relation to adenoma risk. Within a colonoscopy-based case-control study of 628 adenoma cases and 516 polyp-free controls, we analyzed two tagSNPs in WNT6 (rs6747776 G > C, rs6754599 G > C) and WNT10A (rs7349332 G > A, rs10177996 A > G). The WNT6 rs6747776 homozygous minor allele (CC) was associated with increased risk of colorectal adenoma (OR = 2.75, 95% CI: 1.03-7.31). We observed a statistically significant interaction between WNT6 rs6747776 and the proportion of calories from total fat (P-int = 0.02), where the highest risk was observed among those with minor alleles and lowest fat intake. We also detected a marginally significant (0.05 < P ≤ 0.10) interaction with fish intake (P-int = 0.09). Additionally, a marginally significant interaction was observed between proportion of calories from saturated fat and the WNT10A rs7349332 polymorphism. Our results suggest that genetic variability in the WNT pathway may play a role in colorectal adenoma formation or may partly mediate the increased risk of colorectal cancer associated with fat intake.