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Verfasst von:Meyer, Lukas [VerfasserIn]   i
 Stracke, Paul [VerfasserIn]   i
 Broocks, Gabriel [VerfasserIn]   i
 Elsharkawy, Mohamed [VerfasserIn]   i
 Sporns, Peter B. [VerfasserIn]   i
 Piechowiak, Eike Immo [VerfasserIn]   i
 Kaesmacher, Johannes [VerfasserIn]   i
 Maegerlein, Christian [VerfasserIn]   i
 Hernández Petzsche, Moritz Roman [VerfasserIn]   i
 Zimmermann, Hanna [VerfasserIn]   i
 Naziri, Weis [VerfasserIn]   i
 Abdullayev, Nuran [VerfasserIn]   i
 Kabbasch, Christoph [VerfasserIn]   i
 Diamandis, Elie [VerfasserIn]   i
 Thormann, Maximilian [VerfasserIn]   i
 Maus, Volker [VerfasserIn]   i
 Fischer, Sebastian [VerfasserIn]   i
 Möhlenbruch, Markus Alfred [VerfasserIn]   i
 Weyland, Charlotte S. [VerfasserIn]   i
 Ernst, Marielle Sophie Katherine [VerfasserIn]   i
 Jamous, Ala [VerfasserIn]   i
 Meila, Dan Doru [VerfasserIn]   i
 Miszczuk, Milena [VerfasserIn]   i
 Siebert, Eberhard [VerfasserIn]   i
 Lowens, Stephan [VerfasserIn]   i
 Krause, Lars Udo [VerfasserIn]   i
 Yeo, Leonard L. L. [VerfasserIn]   i
 Tan, Benjamin [VerfasserIn]   i
 Gopinathan, Anil [VerfasserIn]   i
 Arenillas-Lara, Juan F. [VerfasserIn]   i
 Navia, Pedro [VerfasserIn]   i
 Raz, Eytan [VerfasserIn]   i
 Shapiro, Maksim [VerfasserIn]   i
 Arnberg, Fabian [VerfasserIn]   i
 Zeleňák, Kamil [VerfasserIn]   i
 Martínez-Galdámez, Mario [VerfasserIn]   i
 Alexandrou, Maria [VerfasserIn]   i
 Kastrup, Andreas [VerfasserIn]   i
 Papanagiotou, Panagiotis [VerfasserIn]   i
 Kemmling, André [VerfasserIn]   i
 Dorn, Franziska [VerfasserIn]   i
 Psychogios, Marios-Nikos [VerfasserIn]   i
 Andersson, Tommy [VerfasserIn]   i
 Chapot, René [VerfasserIn]   i
 Fiehler, Jens [VerfasserIn]   i
 Hanning, Uta [VerfasserIn]   i
 Roth, Christian [VerfasserIn]   i
 Politi, Maria [VerfasserIn]   i
 Galván, Jorge [VerfasserIn]   i
 Schüller, Miguel [VerfasserIn]   i
 Wallocha, Marta [VerfasserIn]   i
 Cantré, Daniel [VerfasserIn]   i
 Gory, Benjamin [VerfasserIn]   i
 Richard, Sébastien [VerfasserIn]   i
Titel:Thrombectomy versus medical management for isolated anterior cerebral artery stroke
Titelzusatz:an international multicenter registry study
Verf.angabe:Lukas Meyer, Paul Stracke, Gabriel Broocks, Mohamed Elsharkawy, Peter Sporns, Eike I. Piechowiak, Johannes Kaesmacher, Christian Maegerlein, Moritz Roman Hernandez Petzsche, Hanna Zimmermann, Weis Naziri, Nuran Abdullayev, Christoph Kabbasch, Elie Diamandis, Maximilian Thormann, Volker Maus, Sebastian Fischer, Markus Möhlenbruch, Charlotte S. Weyland, Marielle Ernst, Ala Jamous, Dan Meila, Milena Miszczuk, Eberhard Siebert, Stephan Lowens, Lars Udo Krause, Leonard Yeo, Benjamin Tan, Anil Gopinathan, Juan F. Arenillas-Lara, Pedro Navia, Eytan Raz, Maksim Shapiro, Fabian Arnberg, Kamil Zeleňák, Mario Martínez-Galdámez, Maria Alexandrou, Andreas Kastrup, Panagiotis Papanagiotou, André Kemmling, Franziska Dorn, Marios Psychogios, Tommy Andersson, René Chapot, Jens Fiehler, Uta Hanning, for the TOPMOST Study Group
E-Jahr:2023
Jahr:Feb 14 2023
Umfang:11 S.
Fussnoten:Gesehen am 17.07.2023
Titel Quelle:Enthalten in: Radiology
Ort Quelle:Oak Brook, Ill. : Soc., 1923
Jahr Quelle:2023
Band/Heft Quelle:307(2023), 2 vom: Feb., Artikel-ID e220229, Seite 1-11
ISSN Quelle:1527-1315
Abstract:Background - - Evidence supporting a potential benefit of thrombectomy for distal medium vessel occlusions (DMVOs) of the anterior cerebral artery (ACA) is, to the knowledge of the authors, unknown. - - Purpose - - To compare the clinical and safety outcomes between mechanical thrombectomy (MT) and best medical treatment (BMT) with or without intravenous thrombolysis for primary isolated ACA DMVOs. - - Materials and Methods - - Treatment for Primary Medium Vessel Occlusion Stroke, or TOPMOST, is an international, retrospective, multicenter, observational registry of patients treated for DMVO in daily practice. Patients treated with thrombectomy or BMT alone for primary ACA DMVO distal to the A1 segment between January 2013 and October 2021 were analyzed and compared by one-to-one propensity score matching (PSM). Early outcome was measured by the median improvement of National Institutes of Health Stroke Scale (NIHSS) scores at 24 hours. Favorable functional outcome was defined as modified Rankin scale scores of 0-2 at 90 days. Safety was assessed by the occurrence of symptomatic intracerebral hemorrhage and mortality. - - Results - - Of 154 patients (median age, 77 years; quartile 1 [Q1] to quartile 3 [Q3], 66-84 years; 80 men; 94 patients with MT; 60 patients with BMT) who met the inclusion criteria, 110 patients (median age, 76 years; Q1-Q3, 67-83 years; 50 men; 55 patients with MT; 55 patients with BMT) were matched. DMVOs were in A2 (82 patients; 53%), A3 (69 patients; 45%), and A3 (three patients; 2%). After PSM, the median 24-hour NIHSS point decrease was −2 (Q1-Q3, −4 to 0) in the thrombectomy and −1 (Q1-Q3, −4 to 1.25) in the BMT cohort (P = .52). Favorable functional outcome (MT vs BMT, 18 of 37 [49%] vs 19 of 39 [49%], respectively; P = .99) and mortality (MT vs BMT, eight of 37 [22%] vs 12 of 39 [31%], respectively; P = .36) were similar in both groups. Symptomatic intracranial hemorrhage occurred in three (2%) of 154 patients. - - Conclusion - - Thrombectomy appears to be a safe and technically feasible treatment option for primary isolated anterior cerebral artery occlusions in the A2 and A3 segment with clinical outcomes similar to best medical treatment with and without intravenous thrombolysis.
DOI:doi:10.1148/radiol.220229
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1148/radiol.220229
 Volltext: https://pubs.rsna.org/doi/10.1148/radiol.220229
 DOI: https://doi.org/10.1148/radiol.220229
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1852792442
Verknüpfungen:→ Zeitschrift

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