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| Verfasst von: | Oraki Kohshour, Mojtaba [VerfasserIn]  |
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| | Kannaiyan, Nirmal R. [VerfasserIn] |
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| | Falk, August Jernbom [VerfasserIn] |
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| | Papiol, Sergi [VerfasserIn] |
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| | Heilbronner, Urs [VerfasserIn] |
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| | Budde, Monika [VerfasserIn] |
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| | Kálmán, János L. [VerfasserIn] |
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| | Schulte, Eva C. [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| | Witt, Stephanie [VerfasserIn] |
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| | Forstner, Andreas Josef [VerfasserIn] |
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| | Heilmann, Stefanie [VerfasserIn] |
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| | Nöthen, Markus M. [VerfasserIn] |
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| | Spitzer, Carsten [VerfasserIn] |
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| | Malchow, Berend [VerfasserIn] |
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| | Müller, Thorsten [VerfasserIn] |
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| | Wiltfang, Jens [VerfasserIn] |
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| | Falkai, Peter [VerfasserIn] |
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| | Schmitt, Andrea [VerfasserIn] |
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| | Roßner, Moritz [VerfasserIn] |
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| | Nilsson, Peter [VerfasserIn] |
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| | Schulze, Thomas Gerd [VerfasserIn] |
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| Titel: | Comparative serum proteomic analysis of a selected protein panel in individuals with schizophrenia and bipolar disorder and the impact of genetic risk burden on serum proteomic profiles |
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| Verf.angabe: | Mojtaba Oraki Kohshour, Nirmal R. Kannaiyan, August Jernbom Falk, Sergi Papiol, Urs Heilbronner, Monika Budde, Janos L. Kalman, Eva C. Schulte, Marcella Rietschel, Stephanie Witt, Andreas J. Forstner, Stefanie Heilmann-Heimbach, Markus M. Nöthen, Carsten Spitzer, Berend Malchow, Thorsten Müller, Jens Wiltfang, Peter Falkai, Andrea Schmitt, Moritz J. Rossner, Peter Nilsson and Thomas G. Schulze |
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| E-Jahr: | 2022 |
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| Jahr: | 09 November 2022 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 17.07.2023 |
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| Titel Quelle: | Enthalten in: Translational Psychiatry |
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| Ort Quelle: | London : Nature Publishing Group, 2011 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 12(2022), Artikel-ID 471, Seite 1-6 |
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| ISSN Quelle: | 2158-3188 |
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| Abstract: | The diagnostic criteria for schizophrenia (SCZ) and bipolar disorder (BD) are based on clinical assessments of symptoms. In this pilot study, we applied high-throughput antibody-based protein profiling to serum samples of healthy controls and individuals with SCZ and BD with the aim of identifying differentially expressed proteins in these disorders. Moreover, we explored the influence of polygenic burden for SCZ and BD on the serum levels of these proteins. Serum samples from 113 individuals with SCZ and 125 with BD from the PsyCourse Study and from 44 healthy controls were analyzed by using a set of 155 antibodies in an antibody-based assay targeting a selected panel of 95 proteins. For the cases, genotyping and imputation were conducted for DNA samples and SCZ and BD polygenic risk scores (PRS) were calculated. Univariate linear and logistic models were used for association analyses. The comparison between SCZ and BD revealed two serum proteins that were significantly elevated in BD after multiple testing adjustment: “complement C9” and “Interleukin 1 Receptor Accessory Protein”. Moreover, the first principal component of variance in the proteomics dataset differed significantly between SCZ and BD. After multiple testing correction, SCZ-PRS, BD-PRS, and SCZ-vs-BD-PRS were not significantly associated with the levels of the individual proteins or the values of the proteome principal components indicating no detectable genetic effects. Overall, our findings contribute to the evidence suggesting that the analysis of circulating proteins could lead to the identification of distinctive biomarkers for SCZ and BD. Our investigation warrants replication in large-scale studies to confirm these findings. |
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| DOI: | doi:10.1038/s41398-022-02228-x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41398-022-02228-x |
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| | kostenfrei: Volltext: http://www.nature.com/articles/s41398-022-02228-x |
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| | DOI: https://doi.org/10.1038/s41398-022-02228-x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Diagnostic markers |
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| | Human behaviour |
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| | Psychiatric disorders |
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| K10plus-PPN: | 1852811811 |
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| Verknüpfungen: | → Zeitschrift |
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Comparative serum proteomic analysis of a selected protein panel in individuals with schizophrenia and bipolar disorder and the impact of genetic risk burden on serum proteomic profiles / Oraki Kohshour, Mojtaba [VerfasserIn]; 09 November 2022 (Online-Ressource)
