| |  Online-Ressource |
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| Verfasst von: | Shigoka, Masatoshi [VerfasserIn]  |
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| | Tsuchida, Akihiko [VerfasserIn] |
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| | Matsudo, Takaaki [VerfasserIn] |
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| | Nagakawa, Yuichi [VerfasserIn] |
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| | Saito, Hitoshi [VerfasserIn] |
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| | Suzuki, Yoshiaki [VerfasserIn] |
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| | Aoki, Tatsuya [VerfasserIn] |
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| | Murakami, Yoshiki [VerfasserIn] |
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| | Toyoda, Hidenori [VerfasserIn] |
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| | Kumada, Takashi [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | Kato, Nobuyuki [VerfasserIn] |
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| | Ikeda, Masanori [VerfasserIn] |
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| | Takashina, Tomoki [VerfasserIn] |
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| | Tanaka, Masami [VerfasserIn] |
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| | Suzuki, Rieko [VerfasserIn] |
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| | Oikawa, Kosuke [VerfasserIn] |
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| | Takanashi, Masakatsu [VerfasserIn] |
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| | Kuroda, Masahiko [VerfasserIn] |
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| Titel: | Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development |
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| Verf.angabe: | Masatoshi Shigoka, Akihiko Tsuchida, Takaaki Matsudo, Yuichi Nagakawa, Hitoshi Saito, Yoshiaki Suzuki, Tatsuya Aoki, Yoshiki Murakami, Hidenori Toyoda, Takashi Kumada, Ralf Bartenschlager, Nobuyuki Kato, Masanori Ikeda, Tomoki Takashina, Masami Tanaka, Rieko Suzuki, Kosuke Oikawa, Masakatsu Takanashi and Masahiko Kuroda |
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| E-Jahr: | 2010 |
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| Jahr: | 29 April 2010 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 17.07.2023 |
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| Titel Quelle: | Enthalten in: Pathology international |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1951 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 60(2010), 5, Seite 351-357 |
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| ISSN Quelle: | 1440-1827 |
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| Abstract: | MicroRNAs (miRNAs) belong to a class of the endogenously expressed non-coding small RNAs which primarily function as gene regulators. Growing evidence suggests that miRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis. The miR-17-92 cluster especially is markedly overexpressed in several cancers, and is associated with the cancer development and progression. In this study, we have demonstrated that miR-92a is highly expressed in hepatocellular carcinoma (HCC). In addition, the proliferation of HCC-derived cell lines was enhanced by miR-92a and inhibited by the anti-miR-92a antagomir. On the other hand, we have found that the relative amount of miR-92a in the plasmas from HCC patients is decreased compared with that from the healthy donors. Interestingly, the amount of miR-92a was elevated after surgical treatment. Thus, although the physiological significance of the decrease of miR-92a in plasma is still unknown, deregulation of miR-92 expression in cells and plasma should be implicated in the development of HCC. |
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| DOI: | doi:10.1111/j.1440-1827.2010.02526.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1111/j.1440-1827.2010.02526.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1440-1827.2010.02526.x |
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| | DOI: https://doi.org/10.1111/j.1440-1827.2010.02526.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | hepatocellular carcinoma |
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| | microRNA |
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| | miR-638 |
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| | miR-92a |
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| | plasma |
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| K10plus-PPN: | 1852825464 |
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| Verknüpfungen: | → Zeitschrift |
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Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development / Shigoka, Masatoshi [VerfasserIn]; 29 April 2010 (Online-Ressource)
