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| Verfasst von: | Sirrenberg-Cruciat, Cristina-Maria [VerfasserIn]  |
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| | Ohkawara, Bisei [VerfasserIn] |
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| | Acebron, Sergio P. [VerfasserIn] |
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| | Karaulanov, Emil [VerfasserIn] |
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| | Reinhard, Carmen [VerfasserIn] |
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| | Ingelfinger, Dierk [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| | Niehrs, Christof [VerfasserIn] |
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| Titel: | Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling |
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| Verf.angabe: | Cristina-Maria Cruciat, Bisei Ohkawara, Sergio P. Acebron, Emil Karaulanov, Carmen Reinhard, Dierk Ingelfinger, Michael Boutros, Christof Niehrs |
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| E-Jahr: | 2010 |
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| Jahr: | January 22, 2010 |
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| Umfang: | 5 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Im Titel ist "+" hochgestellt ; Gesehen am 19.07.2023 |
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| Titel Quelle: | Enthalten in: Science |
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| Ort Quelle: | Washington, DC : American Association for the Advancement of Science, 1880 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 327(2010), 5964 vom: Jan., Seite 459-463 |
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| ISSN Quelle: | 1095-9203 |
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| Abstract: | Wnt/beta-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal transmission, notably how the receptors are activated, remains incompletely understood. We found that the prorenin receptor (PRR) is a component of the Wnt receptor complex. PRR functions in a renin-independent manner as an adaptor between Wnt receptors and the vacuolar H+-adenosine triphosphatase (V-ATPase) complex. Moreover, PRR and V-ATPase were required to mediate Wnt signaling during antero-posterior patterning of Xenopus early central nervous system development. The results reveal an unsuspected role for the prorenin receptor, V-ATPase activity, and acidification during Wnt/beta-catenin signaling. |
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| DOI: | doi:10.1126/science.1179802 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1126/science.1179802 |
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| | DOI: https://doi.org/10.1126/science.1179802 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | beta Catenin |
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| | Body Patterning |
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| | Cell Line |
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| | Cell Line, Tumor |
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| | Central Nervous System |
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| | Embryo, Nonmammalian |
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| | Frizzled Receptors |
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| | Gene Expression Regulation, Developmental |
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| | Homeodomain Proteins |
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| | Humans |
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| | Hydrogen-Ion Concentration |
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| | LDL-Receptor Related Proteins |
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| | Low Density Lipoprotein Receptor-Related Protein-6 |
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| | Mice |
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| | Nerve Tissue Proteins |
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| | Phosphorylation |
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| | Prorenin Receptor |
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| | Receptors, Cell Surface |
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| | RNA, Small Interfering |
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| | Signal Transduction |
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| | Vacuolar Proton-Translocating ATPases |
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| | Wnt Proteins |
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| | Wnt3 Protein |
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| | Xenopus |
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| | Xenopus Proteins |
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| K10plus-PPN: | 1853080179 |
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| Verknüpfungen: | → Zeitschrift |
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Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling / Sirrenberg-Cruciat, Cristina-Maria [VerfasserIn]; January 22, 2010 (Online-Ressource)
