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| Verfasst von: | Fresnais, Margaux [VerfasserIn]  |
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| | Liang, Siwen [VerfasserIn] |
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| | Seven, Deniz [VerfasserIn] |
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| | Prodanovic, Nevena [VerfasserIn] |
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| | Sundheimer, Julia [VerfasserIn] |
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| | Haefeli, Walter E. [VerfasserIn] |
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| | Burhenne, Jürgen [VerfasserIn] |
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| | Longuespée, Rémi [VerfasserIn] |
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| Titel: | Desorption kinetics evaluation for the development of validated desorption electrospray ionization-mass spectrometric assays for drug quantification in tissue sections |
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| Verf.angabe: | Margaux Fresnais, Siwen Liang, Deniz Seven, Nevena Prodanovic, Julia Sundheimer, Walter E. Haefeli, Jürgen Burhenne and Rémi Longuespée |
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| E-Jahr: | 2023 |
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| Jahr: | 9 May 2023 |
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| Umfang: | 14 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 30.11.2023 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 24(2023), 10, Artikel-ID 8469, Seite 1-14 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | The development of desorption/ionization (DI) mass spectrometric (MS) assays for drug quantification in tissue sections and their validation according to regulatory guidelines would enable their universalization for applications in (clinical) pharmacology. Recently, new enhancements in desorption electrospray ionization (DESI) have highlighted the reliability of this ion source for the development of targeted quantification methods that meet requirements for method validation. However, it is necessary to consider subtle parameters leading to the success of such method developments, such as the morphology of desorption spots, the analytical time, and sample surface, to cite but a few. Here, we provide additional experimental data highlighting an additional important parameter, based on the unique advantage of DESI-MS on continuous extraction during analysis. ... |
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| DOI: | doi:10.3390/ijms24108469 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms24108469 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/24/10/8469 |
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| | DOI: https://doi.org/10.3390/ijms24108469 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | desorption electrospray ionization |
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| | drug quantification |
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| | mass spectrometry |
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| K10plus-PPN: | 185316223X |
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| Verknüpfungen: | → Zeitschrift |
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Desorption kinetics evaluation for the development of validated desorption electrospray ionization-mass spectrometric assays for drug quantification in tissue sections / Fresnais, Margaux [VerfasserIn]; 9 May 2023 (Online-Ressource)
