| |  Online-Ressource |
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| Verfasst von: | Xiao, Qiyun [VerfasserIn]  |
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| | Werner, Johannes [VerfasserIn] |
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| | Venkatachalam, Nachiyappan [VerfasserIn] |
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| | Boonekamp, Kim E. [VerfasserIn] |
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| | Ebert, Matthias [VerfasserIn] |
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| | Zhan, Tianzuo [VerfasserIn] |
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| Titel: | Cross-talk between p53 and Wnt signaling in cancer |
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| Verf.angabe: | Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, and Tianzuo Zhan |
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| E-Jahr: | 2022 |
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| Jahr: | 15 March 2022 |
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| Umfang: | 21 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 20.07.2023 |
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| Titel Quelle: | Enthalten in: Biomolecules |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 12(2022), 3, Artikel-ID 453, Seite 1-21 |
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| ISSN Quelle: | 2218-273X |
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| Abstract: | Targeting cancer hallmarks is a cardinal strategy to improve antineoplastic treatment. However, cross-talk between signaling pathways and key oncogenic processes frequently convey resistance to targeted therapies. The p53 and Wnt pathway play vital roles for the biology of many tumors, as they are critically involved in cancer onset and progression. Over recent decades, a high level of interaction between the two pathways has been revealed. Here, we provide a comprehensive overview of molecular interactions between the p53 and Wnt pathway discovered in cancer, including complex feedback loops and reciprocal transactivation. The mutational landscape of genes associated with p53 and Wnt signaling is described, including mutual exclusive and co-occurring genetic alterations. Finally, we summarize the functional consequences of this cross-talk for cancer phenotypes, such as invasiveness, metastasis or drug resistance, and discuss potential strategies to pharmacologically target the p53-Wnt interaction. |
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| DOI: | doi:10.3390/biom12030453 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/biom12030453 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2218-273X/12/3/453 |
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| | DOI: https://doi.org/10.3390/biom12030453 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | APC |
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| | beta-catenin |
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| | cancer |
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| | drug resistance |
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| | metastasis |
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| | p53 |
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| | Wnt |
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| K10plus-PPN: | 1853189324 |
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| Verknüpfungen: | → Zeitschrift |
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Cross-talk between p53 and Wnt signaling in cancer / Xiao, Qiyun [VerfasserIn]; 15 March 2022 (Online-Ressource)
