Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Sokolova, Natalia [VerfasserIn]  |
| Zilova, Lucie [VerfasserIn]  |
| Wittbrodt, Joachim [VerfasserIn]  |
Titel: | Unravelling the link between embryogenesis and adult stem cell potential in the ciliary marginal zone |
Titelzusatz: | a comparative study between mammals and teleost fish |
Verf.angabe: | Natalia Sokolova, Lucie Zilova, Joachim Wittbrodt |
E-Jahr: | 2023 |
Jahr: | June 2023 |
Umfang: | 9 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Online verfügbar 10. Mai 2023, Artikelversion 16. Mai 2023 ; Gesehen am 20.07.2023 |
Titel Quelle: | Enthalten in: Cells & development |
Ort Quelle: | Amsterdam : Elsevier, 2021 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 174(2023) vom: Juni, Artikel-ID 203848, Seite 1-9 |
ISSN Quelle: | 2667-2901 |
Abstract: | The discovery and study of adult stem cells have revolutionized regenerative medicine by offering new opportunities for treating various medical conditions. Anamniote stem cells, which retain their full proliferative capacity and full differentiation range throughout their lifetime, harbour a greater potential compared to mammalian adult stem cells, which only exhibit limited stem cell potential. Therefore, understanding the mechanisms underlying these differences is of significant interest. In this review, we examine the similarities and differences of adult retinal stem cells in anamniotes and mammals, from their embryonic stages in the optic vesicle to their residence in the postembryonic retinal stem cell niche, the ciliary marginal zone located in the retinal periphery. In anamniotes, developing precursors of retinal stem cells are exposed to various environmental cues during their migration in the complex morphogenetic remodelling of the optic vesicle to the optic cup. In contrast, their mammalian counterparts in the retinal periphery are primarily instructed by neighbouring tissues once they are in place. We explore the distinct modes of optic cup morphogenesis in mammals and teleost fish and highlight molecular mechanisms governing morphogenesis and stem cells instruction. The review concludes with the molecular mechanisms of ciliary marginal zone formation and offers a perspective on the impact of comparative single cell transcriptomic studies to reveal the evolutionary similarities and differences. |
DOI: | doi:10.1016/j.cdev.2023.203848 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cdev.2023.203848 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S2667290123000244 |
| DOI: https://doi.org/10.1016/j.cdev.2023.203848 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Adult retinal stem cells |
| Anamniotes |
| Ciliary marginal zone |
| Development |
| Eye morphogenesis |
K10plus-PPN: | 1853192457 |
Verknüpfungen: | → Zeitschrift |
Unravelling the link between embryogenesis and adult stem cell potential in the ciliary marginal zone / Sokolova, Natalia [VerfasserIn]; June 2023 (Online-Ressource)
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