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Status: Bibliographieeintrag

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Verfasst von:Sokolova, Natalia [VerfasserIn]   i
 Zilova, Lucie [VerfasserIn]   i
 Wittbrodt, Joachim [VerfasserIn]   i
Titel:Unravelling the link between embryogenesis and adult stem cell potential in the ciliary marginal zone
Titelzusatz:a comparative study between mammals and teleost fish
Verf.angabe:Natalia Sokolova, Lucie Zilova, Joachim Wittbrodt
E-Jahr:2023
Jahr:June 2023
Umfang:9 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar 10. Mai 2023, Artikelversion 16. Mai 2023 ; Gesehen am 20.07.2023
Titel Quelle:Enthalten in: Cells & development
Ort Quelle:Amsterdam : Elsevier, 2021
Jahr Quelle:2023
Band/Heft Quelle:174(2023) vom: Juni, Artikel-ID 203848, Seite 1-9
ISSN Quelle:2667-2901
Abstract:The discovery and study of adult stem cells have revolutionized regenerative medicine by offering new opportunities for treating various medical conditions. Anamniote stem cells, which retain their full proliferative capacity and full differentiation range throughout their lifetime, harbour a greater potential compared to mammalian adult stem cells, which only exhibit limited stem cell potential. Therefore, understanding the mechanisms underlying these differences is of significant interest. In this review, we examine the similarities and differences of adult retinal stem cells in anamniotes and mammals, from their embryonic stages in the optic vesicle to their residence in the postembryonic retinal stem cell niche, the ciliary marginal zone located in the retinal periphery. In anamniotes, developing precursors of retinal stem cells are exposed to various environmental cues during their migration in the complex morphogenetic remodelling of the optic vesicle to the optic cup. In contrast, their mammalian counterparts in the retinal periphery are primarily instructed by neighbouring tissues once they are in place. We explore the distinct modes of optic cup morphogenesis in mammals and teleost fish and highlight molecular mechanisms governing morphogenesis and stem cells instruction. The review concludes with the molecular mechanisms of ciliary marginal zone formation and offers a perspective on the impact of comparative single cell transcriptomic studies to reveal the evolutionary similarities and differences.
DOI:doi:10.1016/j.cdev.2023.203848
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.cdev.2023.203848
 Volltext: https://www.sciencedirect.com/science/article/pii/S2667290123000244
 DOI: https://doi.org/10.1016/j.cdev.2023.203848
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adult retinal stem cells
 Anamniotes
 Ciliary marginal zone
 Development
 Eye morphogenesis
K10plus-PPN:1853192457
Verknüpfungen:→ Zeitschrift

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