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| Verfasst von: | Weusthof, Christopher [VerfasserIn]  |
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| | Burkart, Sebastian [VerfasserIn] |
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| | Semmelmayer, Karl [VerfasserIn] |
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| | Stögbauer, Fabian [VerfasserIn] |
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| | Feng, Bohai [VerfasserIn] |
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| | Khorani, Karam [VerfasserIn] |
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| | Bode, Sebastian Felix Nepomuk [VerfasserIn] |
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| | Plinkert, Peter K. [VerfasserIn] |
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| | Plath, Karim [VerfasserIn] |
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| | Heß, Jochen [VerfasserIn] |
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| Titel: | Establishment of a machine learning model for the risk assessment of perineural invasion in head and neck squamous cell carcinoma |
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| Verf.angabe: | Christopher Weusthof, Sebastian Burkart, Karl Semmelmayer, Fabian Stögbauer, Bohai Feng, Karam Khorani, Sebastian Bode, Peter Plinkert, Karim Plath and Jochen Hess |
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| E-Jahr: | 2023 |
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| Jahr: | 18 May 2023 |
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| Umfang: | 19 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 21.11.2023 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 24(2023), 10, Artikel-ID 8938, Seite 1-19 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Perineural invasion is a prevalent pathological finding in head and neck squamous cell carcinoma and a risk factor for unfavorable survival. An adequate diagnosis of perineural invasion by pathologic examination is limited due to the availability of tumor samples from surgical resection, which can arise in cases of definitive nonsurgical treatment. To address this medical need, we established a random forest prediction model for the risk assessment of perineural invasion, including occult perineural invasion, and characterized distinct cellular and molecular features based on our new and extended classification. RNA sequencing data of head and neck squamous cell carcinoma from The Cancer Genome Atlas were used as a training cohort to identify differentially expressed genes that are associated with perineural invasion. ... |
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| DOI: | doi:10.3390/ijms24108938 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms24108938 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/24/10/8938 |
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| | DOI: https://doi.org/10.3390/ijms24108938 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | hypermethylation |
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| | multiomics |
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| | occult PNI |
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| | random forest |
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| | single-cell sequencing |
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| | somatic mutation |
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| | The Cancer Genome Atlas (TCGA) |
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| K10plus-PPN: | 1853235369 |
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| Verknüpfungen: | → Zeitschrift |
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Establishment of a machine learning model for the risk assessment of perineural invasion in head and neck squamous cell carcinoma / Weusthof, Christopher [VerfasserIn]; 18 May 2023 (Online-Ressource)
