Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs

• Verfasst von: Boutin, Sébastien [VerfasserIn]
• Verfasst von: Hildebrand, Dagmar [VerfasserIn]
• Verfasst von: Boulant, Steeve [VerfasserIn]
• Verfasst von: Kreuter, Michael [VerfasserIn]
• Verfasst von: Rüter, Jule [VerfasserIn]
• Verfasst von: Pallerla, Srinivas Reddy [VerfasserIn]
• Verfasst von: Velavan, Thirumalaisamy P. [VerfasserIn]
• Verfasst von: Nurjadi, Dennis [VerfasserIn]
• Titel: Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs
• Verf.angabe: Sébastien Boutin, Dagmar Hildebrand, Steeve Boulant, Michael Kreuter, Jule Rüter, Srinivas Reddy Pallerla, Thirumalaisamy P. Velavan, Dennis Nurjadi
• E-Jahr: 2021
• Jahr: 05 July 2021
• Umfang: 24 S.
• Fussnoten: Gesehen am 21.07.2023
• Titel Quelle: Enthalten in: Cellular and molecular life sciences
• Ort Quelle: Cham (ZG) : Springer International Publishing AG, 1997
• Jahr Quelle: 2021
• Band/Heft Quelle: 78(2021), 16, Seite 5953-5976
• ISSN Quelle: 1420-9071
• DOI: doi:10.1007/s00018-021-03889-5
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Co-morbidities
• Sach-SW: COVID-19
• Sach-SW: Host factor
• Sach-SW: Innate immune response
• Sach-SW: Microbiome
• Sach-SW: SARS-CoV-2
• K10plus-PPN: 1853358355
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host’s microbiome and secondary infection which also worsen the disease.