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Verfasst von:Schwarz, Markus [VerfasserIn]   i
 Reisig, Gregor [VerfasserIn]   i
 Schneider-Wald, Barbara Katharina [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Hauk, Luisa [VerfasserIn]   i
 Schütte, Andy [VerfasserIn]   i
Titel:Coefficient of friction and height loss: two criteria used to determine the mechanical property and stability of regenerated versus natural articular cartilage
Verf.angabe:Markus L. Schwarz, Gregor Reisig, Barbara Schneider-Wald, Christel Weiß, Luisa Hauk and Andy Schütte
E-Jahr:2022
Jahr: 24 October 2022
Umfang:22 S.
Fussnoten:Gesehen am 25.07.2023
Titel Quelle:Enthalten in: Biomedicines
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2022
Band/Heft Quelle:10(2022), 11, Artikel-ID 2685, Seite 1-22
ISSN Quelle:2227-9059
Abstract:Background: The coefficient of friction (CoF) serves as an indicator for the mechanical properties of natural and regenerated articular cartilage (AC). After tribological exposure, a height loss (HL) of the cartilage pair specimens can be measured. Our aim was to determine the CoF and HL of regenerated AC tissue and compare them with those of natural AC from non-operated joints and AC from joints where the regenerated tissues had been created after different treatments. Methods: In partial-thickness defects of the trochleae of the stifle joints of 60 Göttingen Minipigs, regenerated AC was created. In total, 40 animals received a Col I matrix, 20 laden with autologous chondrocytes, and 20 without. The defects of 20 animals were left empty. The healing periods were 24 and 48 weeks. A total of 10 not-operated animals, delivered the “external” control specimens. Osteochondral pins were harvested from defect and non-defect areas, the latter serving as “internal” controls. Using a pin-on-plate tribometer, we measured the CoF and the HL. Results: The CoF of the regenerated AC ranged from 0.039 to 0.069, and the HL, from 0.22 mm to 0.33 mm. The differences between the regenerated AC of the six groups and the “external” controls were significant. The comparison with the “internal” controls revealed four significant differences for the CoF and one for the HL in the operated groups. No differences were seen within the operated groups. Conclusions: The mechanical quality of the regenerated AC tissue showed inferior behavior with regard to the CoF and HL in comparison with natural AC. The comparison of regenerated AC tissue with AC from untreated joints was more promising than with AC from the treated joints.
DOI:doi:10.3390/biomedicines10112685
URL:kostenfrei: Volltext: https://doi.org/10.3390/biomedicines10112685
 kostenfrei: Volltext: https://www.mdpi.com/2227-9059/10/11/2685
 DOI: https://doi.org/10.3390/biomedicines10112685
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:articular cartilage
 autologous chondrocytes
 coefficient of friction
 controls
 effect size
 Göttingen Minipig
 height loss
 large animal trial
 mechanical property
 regenerative therapy
K10plus-PPN:1853552526
Verknüpfungen:→ Zeitschrift
 
 
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