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| Verfasst von: | Yamada, Yosuke [VerfasserIn]  |
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| | Bohnenberger, Hanibal [VerfasserIn] |
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| | Kriegsmann, Mark [VerfasserIn] |
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| | Kriegsmann, Katharina [VerfasserIn] |
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| | Sinn, Peter [VerfasserIn] |
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| | Goto, Norihiro [VerfasserIn] |
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| | Nakanishi, Yuki [VerfasserIn] |
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| | Seno, Hiroshi [VerfasserIn] |
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| | Chigusa, Yoshitsugu [VerfasserIn] |
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| | Fujimoto, Masakazu [VerfasserIn] |
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| | Minamiguchi, Sachiko [VerfasserIn] |
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| | Haga, Hironori [VerfasserIn] |
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| | Simon, Ronald [VerfasserIn] |
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| | Sauter, Guido [VerfasserIn] |
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| | Ströbel, Philipp [VerfasserIn] |
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| | Marx, Alexander [VerfasserIn] |
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| Titel: | Tuft cell-like carcinomas |
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| Titelzusatz: | novel cancer subsets present in multiple organs sharing a unique gene expression signature$dmolecular diagnostics |
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| Verf.angabe: | Yosuke Yamada, Hanibal Bohnenberger, Mark Kriegsmann, Katharina Kriegsmann, Peter Sinn, Norihiro Goto, Yuki Nakanishi, Hiroshi Seno, Yoshitsugu Chigusa, Masakazu Fujimoto, Sachiko Minamiguchi, Hironori Haga, Ronald Simon, Guido Sauter, Philipp Ströbel and Alexander Marx |
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| E-Jahr: | 2022 |
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| Jahr: | 23 August 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 31.07.2023 |
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| Titel Quelle: | Enthalten in: British journal of cancer |
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| Ort Quelle: | Edinburgh : Nature Publ. Group, 1999 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 127(2022), 10 vom: Nov., Seite 1876-1885 |
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| ISSN Quelle: | 1532-1827 |
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| Abstract: | Background: Tuft cells are chemosensory epithelial cells playing a role in innate immunity. Recent studies revealed cancers with a tuft cell-like gene expression signature in the thorax. We wondered whether this signature might also occur in extrathoracic cancers. Methods: We examined mRNA expression of tuft cell markers (POU2F3, GFI1B, TRPM5, SOX9, CHAT, and AVIL) in 19 different types of cancers in multiple extrathoracic organs with The Cancer Genome Atlas (TCGA) (N = 6322). Four different extrathoracic cancers in our local archives (N = 909) were analysed by immunohistochemistry. Results: Twenty-two (0.35%) extrathoracic tumours with co-expression of POU2F3 and other tuft cell markers were identified in various TCGA datasets. Twelve of the 22 “tuft cell-like tumours” shared poor differentiation and a gene expression pattern, including KIT, anti-apoptotic BCL2, and ionocyte-associated genes. In our archival cases, eleven (1.21%) tumours co-expressing POU2F3, KIT, and BCL2 on immunohistochemistry, i.e., were presumable tuft cell-like cancers. In three among five TCGA cohorts, the tuft cell-like cancer subsets expressed SLFN11, a promising biomarker of PARP inhibitor susceptibility. Conclusions: Tuft cell-like carcinomas form distinct subsets in cancers of many organs. It appears warranted to investigate their shared gene expression signature as a predictive biomarker for novel therapeutic strategies. |
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| DOI: | doi:10.1038/s41416-022-01957-6 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41416-022-01957-6 |
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| | kostenfrei: Volltext: http://www.nature.com/articles/s41416-022-01957-6 |
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| | DOI: https://doi.org/10.1038/s41416-022-01957-6 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Oncogenes |
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| K10plus-PPN: | 1853938939 |
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| Verknüpfungen: | → Zeitschrift |
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Tuft cell-like carcinomas / Yamada, Yosuke [VerfasserIn]; 23 August 2022 (Online-Ressource)
