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| Verfasst von: | Bruns, Bastian [VerfasserIn]  |
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| | Antoniou, Marilena [VerfasserIn] |
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| | Baier, Irena [VerfasserIn] |
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| | Joos, Maximilian [VerfasserIn] |
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| | Sevinchan, Meryem [VerfasserIn] |
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| | Moog, Marie-Christine [VerfasserIn] |
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| | Dieterich, Christoph [VerfasserIn] |
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| | Friederich, Hans-Christoph [VerfasserIn] |
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| | Herzog, Wolfgang [VerfasserIn] |
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| | Frey, Norbert [VerfasserIn] |
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| | Schultz, Jobst-Hendrik [VerfasserIn] |
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| | Backs, Johannes [VerfasserIn] |
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| Titel: | Calcineurin signaling promotes takotsubo syndrome |
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| Verf.angabe: | Bastian Bruns, Marilena Antoniou, Irena Baier, Maximilian Joos, Meryem Sevinchan, Marie-Christine Moog, Christoph Dieterich, Hans-Christoph Friederich, Hilal Khan, Heather Wilson, Wolfgang Herzog, Dana K. Dawson, Norbert Frey, Jobst-Hendrik Schultz, Johannes Backs |
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| E-Jahr: | 2023 |
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| Jahr: | 13 July 2023 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 01.08.2023 |
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| Titel Quelle: | Enthalten in: Nature cardiovascular research |
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| Ort Quelle: | London : Nature Publishing Group UK, 2022 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 2(2023), 7, Seite 645-655 |
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| ISSN Quelle: | 2731-0590 |
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| Abstract: | Takotsubo syndrome (TTS) is an acute heart failure syndrome that mimics the symptoms of acute myocardial infarction and is often preceded by emotional and/or physical stress. There is currently no treatment for TTS. Here we show that injection of 2.5 mg kg−1 of epinephrine (EPI) into mice recapitulates numerous features of human TTS, including increased myocardial damage and mortality in males. Gene set enrichment analysis of myocardial RNA sequencing after EPI injection revealed significant enrichment of calcineurin-dependent pro-inflammatory gene networks, which was more pronounced in male than in female mice, in agreement with observed sex discrepancies in the mouse phenotype. An increase in calcineurin activity was detected in the circulating cells of patients with TTS, suggesting a systemic nature of the syndrome. Preventive and therapeutic treatment of mice injected with EPI using calcineurin inhibitors cyclosporine and tacrolimus improved heart function and reduced myocardial injury. Our findings suggest that calcineurin inhibition could be a potential therapy for TTS. |
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| DOI: | doi:10.1038/s44161-023-00296-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s44161-023-00296-w |
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| | Volltext: https://www.nature.com/articles/s44161-023-00296-w |
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| | DOI: https://doi.org/10.1038/s44161-023-00296-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cardiovascular diseases |
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| | Molecular biology |
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| K10plus-PPN: | 1854035363 |
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| Verknüpfungen: | → Zeitschrift |
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Calcineurin signaling promotes takotsubo syndrome / Bruns, Bastian [VerfasserIn]; 13 July 2023 (Online-Ressource)
