| |  Online-Ressource |
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| Verfasst von: | Wagner, Steffen [VerfasserIn]  |
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| | Langer, Christine [VerfasserIn] |
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| | Wuerdemann, Nora [VerfasserIn] |
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| | Reiser, Susanne [VerfasserIn] |
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| | Abing, Helen [VerfasserIn] |
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| | Pons-Kühnemann, Jörn [VerfasserIn] |
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| | Prigge, Elena-Sophie [VerfasserIn] |
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| | Knebel Doeberitz, Magnus von [VerfasserIn] |
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| | Gattenlöhner, Stefan [VerfasserIn] |
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| | Waterboer, Tim [VerfasserIn] |
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| | Schroeder, Lea [VerfasserIn] |
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| | Arens, Christoph [VerfasserIn] |
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| | Klußmann, Jens Peter [VerfasserIn] |
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| | Wittekindt, Claus [VerfasserIn] |
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| Titel: | Predictors for survival of patients with squamous cell carcinoma of unknown primary in the head and neck region |
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| Verf.angabe: | Steffen Wagner, Christine Langer, Nora Wuerdemann, Susanne Reiser, Helen Abing, Jörn Pons-Kühnemann, Elena-Sophie Prigge, Magnus von Knebel Doeberitz, Stefan Gattenlöhner, Tim Waterboer, Lea Schroeder, Christoph Arens, Jens Peter Klussmann and Claus Wittekindt |
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| E-Jahr: | 2023 |
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| Jahr: | 6 April 2023 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 01.08.2023 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 15(2023), 7, Artikel-ID 2167, Seite 1-13 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Background: Human papillomavirus (HPV) status is the most important predictor of survival in oropharyngeal squamous cell carcinoma (OPSCC). In patients with cervical lymph node metastases of squamous cell carcinoma of unknown origin (CUPHNSCC), much less is known. Methods: We assessed a consecutive cohort of CUPHNSCC diagnosed from 2000-2018 for HPV DNA, mRNA, p16INK4a (p16) expression, and risk factors to identify prognostic classification markers. Results: In 32/103 (31%) CUPHNSCC, p16 was overexpressed, and high-risk HPV DNA was detected in 18/32 (56.3%). This was mostly consistent with mRNA detection. In recursive partitioning analysis, CUPHNSCC patients were classified into three risk groups according to performance status (ECOG) and p16. Principal component analysis suggests a negative correlation of p16, HPV DNA, and gender in relation to ECOG, as well as a correlation between N stage, extranodal extension, and tobacco/alcohol consumption. Conclusions: Despite obvious differences, CUPHNSCC shares similarities in risk profile with OPSCC. However, the detection of p16 alone appears to be more suitable for the classification of CUPHNSCC than for OPSCC and, in combination with ECOG, allows stratification into three risk groups. In the future, additional factors besides p16 and ECOG may become important in larger studies or cases with special risk profiles. |
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| DOI: | doi:10.3390/cancers15072167 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers15072167 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/15/7/2167 |
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| | DOI: https://doi.org/10.3390/cancers15072167 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | carcinoma of unknown primary (CUP) |
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| | head and neck cancer |
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| | human papillomavirus (HPV) |
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| | oropharyngeal squamous cell carcinomas (OPSCC) |
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| | principal component analysis |
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| | risk model |
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| K10plus-PPN: | 1854059963 |
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| Verknüpfungen: | → Zeitschrift |
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Predictors for survival of patients with squamous cell carcinoma of unknown primary in the head and neck region / Wagner, Steffen [VerfasserIn]; 6 April 2023 (Online-Ressource)
