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Verfasst von:Wink, Michael [VerfasserIn]   i
 Schmeller, Thorsten [VerfasserIn]   i
 Latz-Brüning, Birgit [VerfasserIn]   i
Titel:Modes of action of allelochemical alkaloids
Titelzusatz:interaction with neuroreceptors, DNA, and other molecular targets
Verf.angabe:M. Wink, T. Schmeller, B. Latz-Brüning
Jahr:1998
Umfang:57 S.
Fussnoten:Gesehen am 01.08.2023
Titel Quelle:Enthalten in: Journal of chemical ecology
Ort Quelle:New York, NY [u.a.] : Springer Science + Business Media B.V., 1975
Jahr Quelle:1998
Band/Heft Quelle:24(1998), 11, Seite 1881-1937
ISSN Quelle:1573-1561
Abstract:Several alkaloids are toxic to insects and vertebrates and, in addition, can inhibit the growth of bacteria and plant seedlings. In vitro assays were established to elucidate their modes of action and to understand their allelochemical properties. Basic molecular targets studied, present in all cells, included DNA intercalation, protein biosynthesis, and membrane stability. The degree of DNA intercalation was positively correlated with inhibition of DNA polymerase I, reverse transcriptase, and translation at the molecular level and with toxicity against insects and vertebrates at an organismic level. Inhibition of protein biosynthesis was positively correlated with animal toxicity. Molecular targets studied, present only in animals, included neuroreceptors (alpha1, alpha2, serotonin, muscarinic, and nicotinic acetylcholine receptors) and enzymes related to acetylcholine (acetylcholine esterase and choline acetyltransferase). The degree of binding of alkaloids to adrenergic, serotonin, and muscarinic acetylcholine receptors was positively correlated in G-protein-coupled receptors. Receptor binding and toxicity was correlated in insects. The biochemical properties of alkaloids are discussed. It is postulated that their structures were shaped in a process termed “evolutionary molecular modeling” to interact with a single and, more often, with several molecular targets at the same time. Many alkaloids are compounds with a broad activity spectrum that apparently have evolved as “multipurpose” defense compounds. The evolution of allelochemicals affecting more than one target could be a strategy to counteract adaptations by specialists and to help fight off different groups of enemies.
DOI:doi:10.1023/A:1022315802264
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1023/A:1022315802264
 DOI: https://doi.org/10.1023/A:1022315802264
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:adrenergic receptors
 Alkaloids
 DNA intercalation
 DNA polymerase
 membrane stability
 molecular targets
 muscarinic receptor
 neuroreceptors
 nicotine receptor
 protein biosynthesis
 reverse transcriptase
 serotonin receptor
K10plus-PPN:1854063863
Verknüpfungen:→ Zeitschrift

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