| |  Online-Ressource |
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| Verfasst von: | De Souza Rocha Simonini, Pedro [VerfasserIn]  |
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| | Breiling, Achim [VerfasserIn] |
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| | Gupta, Nibedita [VerfasserIn] |
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| | Malekpour, Mahdi [VerfasserIn] |
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| | Youns, Mahmoud [VerfasserIn] |
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| | Omranipour, Ramesh [VerfasserIn] |
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| | Malekpour, Fatemeh [VerfasserIn] |
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| | Volinia, Stefano [VerfasserIn] |
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| | Croce, Carlo M. [VerfasserIn] |
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| | Najmabadi, Hossein [VerfasserIn] |
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| | Diederichs, Sven [VerfasserIn] |
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| | Sahin, Özgür [VerfasserIn] |
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| | Mayer, Doris [VerfasserIn] |
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| | Lyko, Frank [VerfasserIn] |
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| | Hoheisel, Jörg D. [VerfasserIn] |
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| | Riazalhosseini, Yasser [VerfasserIn] |
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| Titel: | Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells |
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| Verf.angabe: | Pedro de Souza Rocha Simonini, Achim Breiling, Nibedita Gupta, Mahdi Malekpour, Mahmoud Youns, Ramesh Omranipour, Fatemeh Malekpour, Stefano Volinia, Carlo M Croce, Hossein Najmabadi, Sven Diederichs, Ozgür Sahin, Doris Mayer, Frank Lyko, Jörg D Hoheisel, and Yasser Riazalhosseini |
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| E-Jahr: | 2010 |
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| Jahr: | November 14 2010 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 01.08.2023 |
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| Titel Quelle: | Enthalten in: Cancer research |
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| Ort Quelle: | Philadelphia, Pa. : AACR, 1916 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 70(2010), 22, Seite 9175-9184 |
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| ISSN Quelle: | 1538-7445 |
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| Abstract: | Estrogen receptor α (ERα) upregulation causes abnormal cell proliferation in about two thirds of breast cancers, yet understanding of the underlying mechanisms remains incomplete. Here, we show that high expression of the microRNA miR-375 in ERα-positive breast cell lines is a key driver of their proliferation. miR-375 overexpression was caused by loss of epigenetic marks including H3K9me2 and local DNA hypomethylation, dissociation of the transcriptional repressor CTCF from the miR-375 promoter, and interactions of ERα with regulatory regions of miR-375. Inhibiting miR-375 in ERα-positive MCF-7 cells resulted in reduced ERα activation and cell proliferation. A combination of expression profiling from tumor samples and miRNA target prediction identified RASD1 as a potential miR-375 target. Mechanistic investigations revealed that miR-375 regulates RASD1 by targeting the 3′ untranslated region in RASD1 mRNA. Additionally, we found that RASD1 negatively regulates ERα expression. Our findings define a forward feedback pathway in control of ERα expression, highlighting new strategies to treat ERα-positive invasive breast tumors. Cancer Res; 70(22); 9175-84. ©2010 AACR. |
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| DOI: | doi:10.1158/0008-5472.CAN-10-1318 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1158/0008-5472.CAN-10-1318 |
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| | DOI: https://doi.org/10.1158/0008-5472.CAN-10-1318 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1854072641 |
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| Verknüpfungen: | → Zeitschrift |
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Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells / De Souza Rocha Simonini, Pedro [VerfasserIn]; November 14 2010 (Online-Ressource)
