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| Verfasst von: | Sinha, Sharmistha [VerfasserIn]  |
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| | Astani, Akram [VerfasserIn] |
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| | Ghosh, Tuhin [VerfasserIn] |
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| | Schnitzler, Paul [VerfasserIn] |
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| | Ray, Bimalendu [VerfasserIn] |
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| Titel: | Polysaccharides from Sargassum tenerrimum |
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| Titelzusatz: | structural features, chemical modification and anti-viral activity |
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| Verf.angabe: | Sharmistha Sinha, Akram Astani, Tuhin Ghosh, Paul Schnitzler, Bimalendu Ray |
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| E-Jahr: | 2010 |
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| Jahr: | 2010 Feb |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 02.08.2023 |
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| Titel Quelle: | Enthalten in: Phytochemistry |
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| Ort Quelle: | New York, NY [u.a.] : Elsevier Science, 1961 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 71(2010), 2, Seite 235-242 |
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| ISSN Quelle: | 1873-3700 |
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| Abstract: | Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. Here, we exploit an approach to inhibiting HSV infection by using a sulfated fucoidan, and a guluronic acid-rich alginate derived from Sargassum tenerrimum, mimicking the active domain of the entry receptor. These macromolecules have apparent molecular masses of 30±5 and 26±5kDa, respectively. They and their chemically sulfated derivatives showed activity against herpes simplex virus type 1 (HSV-1). Their inhibitory concentration 50% (IC50) values were in the range 0.5-15μg/ml and they lacked cytotoxicity at concentrations up to 1000μg/ml. The anti-HSV activity increased with increasing sulfate ester content. Our results suggest the feasibility of inhibiting HSV infection by blocking viral entry with polysaccharide having specific structure. |
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| DOI: | doi:10.1016/j.phytochem.2009.10.014 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.phytochem.2009.10.014 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0031942209004531 |
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| | DOI: https://doi.org/10.1016/j.phytochem.2009.10.014 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Anti-viral activity |
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| | Fucoidan |
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| | Herpes simplex virus |
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| | Poly-guluronate |
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| | Sargassaceae |
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| K10plus-PPN: | 1854185780 |
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| Verknüpfungen: | → Zeitschrift |
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Polysaccharides from Sargassum tenerrimum / Sinha, Sharmistha [VerfasserIn]; 2010 Feb (Online-Ressource)
