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Status: Bibliographieeintrag

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Verfasst von:Meixner, Eva [VerfasserIn]   i
 Hörner-Rieber, Juliane [VerfasserIn]   i
 Lischalk, Jonathan W. [VerfasserIn]   i
 Eichkorn, Tanja [VerfasserIn]   i
 Krämer, Anna Sabrina [VerfasserIn]   i
 Sandrini, Elisabetta [VerfasserIn]   i
 Paul, Angela [VerfasserIn]   i
 Hoegen-Saßmannshausen, Philipp [VerfasserIn]   i
 Deng, Maximilian [VerfasserIn]   i
 Welzel, Thomas [VerfasserIn]   i
 Erdem, Sinem [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 König, Laila [VerfasserIn]   i
Titel:Management of initial and recurrent radiation-induced contrast enhancements following radiotherapy for brain metastases
Titelzusatz:Clinical and radiological impact of bevacizumab and corticosteroids
Verf.angabe:Eva Meixner, Juliane Hörner-Rieber, Jonathan W. Lischalk, Tanja Eichkorn, Anna Krämer, Elisabetta Sandrini, Angela Paul, Philipp Hoegen, Maximilian Deng, Thomas Welzel, Sinem Erdem, Jürgen Debus, Laila König
E-Jahr:2023
Jahr:16 February 2023
Umfang:8 S.
Fussnoten:Online verfügbar 14 February 2023, Version des Artikels 16 February 2023 ; Gesehen am 02.08.2023
Titel Quelle:Enthalten in: Clinical and translational radiation oncology
Ort Quelle:Amsterdam : Elsevier, 2016
Jahr Quelle:2023
Band/Heft Quelle:39(2023) vom: März, Artikel-ID 100600, Seite 1-8
ISSN Quelle:2405-6308
Abstract:Purpose - The appearance of radiation-induced contrast enhancements (RICE) after radiotherapy for brain metastases can go along with severe neurological impairments. The aim of our analysis was to evaluate radiological changes, the course and recurrence of RICE and identify associated prognostic factors. - Methods - We retrospectively identified patients diagnosed with brain metastases, who were treated with radiotherapy and subsequently developed RICE. Patient demographic and clinical data, radiation-, cancer-, and RICE-treatment, radiological results, and oncological outcomes were reviewed in detail. - Results - A total of 95 patients with a median follow-up of 28.8 months were identified. RICE appeared after a median time of 8.0 months after first radiotherapy and 6.4 months after re-irradiation. Bevacizumab in combination with corticosteroids achieved an improvement of clinical symptoms and imaging features in 65.9% and 75.6% of cases, respectively, both significantly superior compared to treatment with corticosteroids only, and further significantly prolonged RICE-progression-free survival to a median of 5.6 months. Recurrence of RICE after initially improved or stable imaging occurred in 63.1% of cases, significantly more often in patients after re-irradiation and was associated with high mortality of 36.6% after the diagnosis of flare-up. Response of recurrence significantly depended on the applied treatment and multiple courses of bevacizumab achieved good response. - Conclusion - Our results suggest that bevacizumab in combination with corticosteroids is superior in achieving short-term imaging and symptom improvement of RICE and prolongs the progression-free time compared to corticosteroids alone. Long-term RICE flare-up rates after bevacizumab discontinuation are high, but repeated treatments achieved effective symptomatic control.
DOI:doi:10.1016/j.ctro.2023.100600
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ctro.2023.100600
 Volltext: https://www.sciencedirect.com/science/article/pii/S2405630823000253
 DOI: https://doi.org/10.1016/j.ctro.2023.100600
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:anti-VEGF antibody Bevacizumab
 Blood brain barrier disruption
 Chemotherapy
 Radiation necrosis
 Re-irradiation. stereotactic radiosurgery
K10plus-PPN:1854190512
Verknüpfungen:→ Zeitschrift

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