Early breast cancer precursor lesions

• Verfasst von: Sinn, Peter [VerfasserIn]
• Verfasst von: Elsawaf, Zeinab [VerfasserIn]
• Verfasst von: Helmchen, Birgit [VerfasserIn]
• Verfasst von: Aulmann, Sebastian [VerfasserIn]
• Titel: Early breast cancer precursor lesions
• Titelzusatz: lessons learned from molecular and clinical studies
• Verf.angabe: Hans-Peter Sinn, Zeinab Elsawaf, Birgit Helmchen, Sebastian Aulmann
• E-Jahr: 2010
• Jahr: August 23, 2010
• Umfang: 9 S.
• Fussnoten: Gesehen am 03.08.2023
• Titel Quelle: Enthalten in: Breast care
• Ort Quelle: Basel : Karger, 2006
• Jahr Quelle: 2010
• Band/Heft Quelle: 5(2010), 4, Seite 218-226
• ISSN Quelle: 1661-3805
• DOI: doi:10.1159/000319624
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1854294253

Abstract

Atypical ductal hyperplasia (ADH), flat epithelial atypia (FEA), and lobular neoplasia (LN) form a group of early precursor lesions that are part of the low-grade pathway in breast cancer development. This concept implies that the neoplastic disease process begins at a stage much earlier than in situ carcinoma. We have performed a review of the published literature for the upgrade risk to ductal carcinoma in situ or invasive carcinoma in open biopsy after a diagnosis of ADH, FEA, or LN in core needle biopsy. This has revealed the highest upgrade risk for ADH (28.2% after open biopsy), followed by LN (14.9%), and FEA (10.2%). With LN, the pleomorphic subtype is believed to confer a higher risk than classical LN. With all types of precursor lesions, careful attention must be paid to the clinicopathological correlation for the guidance of the clinical management. Follow-up biopsies are generally indicated in ADH, and if there is any radiological-pathological discrepancy, also in LN or FEA.