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| Verfasst von: | Birkhold, Megan [VerfasserIn]  |
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| | Datta, Shrimati [VerfasserIn] |
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| | Pak, Gi Deok [VerfasserIn] |
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| | Im, Justin [VerfasserIn] |
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| | Ogundoyin, Olakayode O [VerfasserIn] |
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| | Olulana, Dare I [VerfasserIn] |
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| | Lawal, Taiwo A [VerfasserIn] |
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| | Afuwape, Oludolapo O [VerfasserIn] |
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| | Kehinde, Aderemi [VerfasserIn] |
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| | Phoba, Marie-France [VerfasserIn] |
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| | Nkoji, Gaëlle [VerfasserIn] |
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| | Aseffa, Abraham [VerfasserIn] |
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| | Teferi, Mekonnen [VerfasserIn] |
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| | Yeshitela, Biruk [VerfasserIn] |
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| | Popoola, Oluwafemi [VerfasserIn] |
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| | Owusu, Michael [VerfasserIn] |
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| | Nana, Lady Rosny Wandji [VerfasserIn] |
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| | Cakpo, Enoch G [VerfasserIn] |
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| | Ouedraogo, Moussa [VerfasserIn] |
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| | Ouangre, Edgar [VerfasserIn] |
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| | Ouedraogo, Isso [VerfasserIn] |
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| | Heroes, Anne-Sophie [VerfasserIn] |
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| | Jacobs, Jan [VerfasserIn] |
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| | Mogeni, Ondari D [VerfasserIn] |
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| | Haselbeck, Andrea [VerfasserIn] |
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| | Sukri, Leah [VerfasserIn] |
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| | Neuzil, Kathleen M [VerfasserIn] |
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| | Metila, Octavie Lunguya [VerfasserIn] |
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| | Owusu-Dabo, Ellis [VerfasserIn] |
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| | Adu-Sarkodie, Yaw [VerfasserIn] |
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| | Bassiahi, Abdramane Soura [VerfasserIn] |
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| | Rakotozandrindrainy, Raphaël [VerfasserIn] |
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| | Okeke, Iruka N [VerfasserIn] |
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| | Zellweger, Raphaël M [VerfasserIn] |
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| | Marks, Florian [VerfasserIn] |
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| Titel: | Characterization of typhoid intestinal perforation in Africa |
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| Titelzusatz: | results from the severe typhoid fever surveillance in Africa program |
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| Verf.angabe: | Megan Birkhold, Shrimati Datta, Gi Deok Pak, Justin Im, Olakayode O. Ogundoyin, Dare I. Olulana, Taiwo A. Lawal, Oludolapo O. Afuwape, Aderemi Kehinde, Marie-France Phoba, Gaëlle Nkoji, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Oluwafemi Popoola, Michael Owusu, Lady Rosny Wandji Nana, Enoch G. Cakpo, Moussa Ouedraogo, Edgar Ouangre, Isso Ouedraogo, Anne-Sophie Heroes, Jan Jacobs, Ondari D. Mogeni, Andrea Haselbeck, Leah Sukri, Kathleen M. Neuzil, Octavie Lunguya Metila, Ellis Owusu-Dabo, Yaw Adu-Sarkodie, Abdramane Soura Bassiahi, Raphaël Rakotozandrindrainy, Iruka N. Okeke, Raphaël M. Zellweger, and Florian Marks |
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| E-Jahr: | 2023 |
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| Jahr: | May 2023 |
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| Umfang: | 7 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 02. Juni 2023 ; Gesehen am 07.08.2023 |
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| Titel Quelle: | Enthalten in: Open Forum Infectious Diseases |
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| Ort Quelle: | Oxford : Oxford University Press, 2014 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 10(2023), Supplement_1$m5, Seite S67-S73 |
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| ISSN Quelle: | 2328-8957 |
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| Abstract: | Typhoid intestinal perforation (TIP) remains the most serious complication of typhoid fever. In many countries, the diagnosis of TIP relies on intraoperative identification, as blood culture and pathology capacity remain limited. As a result, many cases of TIP may not be reported as typhoid. This study demonstrates the burden of TIP in sites in Burkina Faso, Democratic Republic of Congo (DRC), Ethiopia, Ghana, Madagascar, and Nigeria.Patients with clinical suspicion of nontraumatic intestinal perforation were enrolled and demographic details, clinical findings, surgical records, blood cultures, tissue biopsies, and peritoneal fluid were collected. Participants were then classified as having confirmed TIP, probable TIP, possible TIP, or clinical intestinal perforation based on surgical descriptions and cultures.A total of 608 participants were investigated for nontraumatic intestinal perforation; 214 (35%) participants had surgically-confirmed TIP and 33 participants (5%) had culture-confirmed typhoid. The overall proportion of blood or surgical site Salmonella enterica subspecies enterica serovar Typhi positivity in surgically verified TIP cases was 10.3%. TIP was high in children aged 5-14 years in DRC, Ghana, and Nigeria. We provide evidence for correlation between monthly case counts of S. Typhi and the occurrence of intestinal perforation.Low S. Typhi culture positivity rates, as well as a lack of blood and tissue culture capability in many regions where typhoid remains endemic, significantly underestimate the true burden of typhoid fever. The occurrence of TIP may indicate underlying typhoid burden, particularly in countries with limited culture capability. |
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| DOI: | doi:10.1093/ofid/ofad138 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/ofid/ofad138 |
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| | DOI: https://doi.org/10.1093/ofid/ofad138 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1854456814 |
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| Verknüpfungen: | → Zeitschrift |
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Characterization of typhoid intestinal perforation in Africa / Birkhold, Megan [VerfasserIn]; May 2023 (Online-Ressource)
