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| Verfasst von: | Schneider, Tobias [VerfasserIn]  |
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| | Filip, Julia [VerfasserIn] |
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| | Soares, Sabrina [VerfasserIn] |
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| | Sohns, Kyra [VerfasserIn] |
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| | Carr, Richard [VerfasserIn] |
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| | Rukwied, Roman [VerfasserIn] |
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| | Schmelz, Martin [VerfasserIn] |
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| Titel: | Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers |
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| Verf.angabe: | Tobias Schneider, Julia Filip, Sabrina Soares, Kyra Sohns, Richard Carr, Roman Rukwied, Martin Schmelz |
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| E-Jahr: | 2023 |
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| Jahr: | June 2023 |
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| Umfang: | 13 S. |
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| Fussnoten: | Online verfügbar: 18. Januar 2023, Artikelversion: 6. Juni 2023 ; Gesehen am 08.08.2023 |
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| Titel Quelle: | Enthalten in: The journal of pain |
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| Ort Quelle: | New York, NY : Elsevier, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 24(2023), 6 vom: Juni, Seite 957-969 |
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| ISSN Quelle: | 1528-8447 |
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| Abstract: | Classically, to electrically excite C-nociceptors, rectangular pulses are used with a duration close to the estimated chronaxie of C-fibres (about 2 ms). Recent results using slow depolarizing stimuli suggest longer chronaxies. We therefore set out to optimize C-fiber stimulation based on recordings of single C-nociceptors in-vivo and C-fiber compound-action-potentials (C-CAP) ex-vivo using half-sine shaped stimuli of durations between 1 and 250ms. Single fiber (n = 45) recording in pigs revealed high chronaxie values for C-touch fibers (15.8 ms), polymodal- (14.2 ms) and silent-nociceptors (16.8 ms). Activation thresholds decreased 2 to 3-fold in all fibre classes when increasing the duration of half-sine pulses from 1 to 25 ms (P < .05). C-CAPs strength-duration curves of the pig saphenous nerve (n = 7) showed the highest sensitivity for half-sine durations between 10 and 25 ms. Half-maximum currents for C-CAPS were reduced 3-fold compared to rectangular pulses (P < .01) whereas the opposite was found for A-fiber compound action potentials. Psychophysics in humans (n = 23) revealed that half-sine stimulus durations >10 ms reduced detection thresholds, pain thresholds, and stimulus current amplitudes required to generate a pain rating of 3 on an 11-point Numeric Rating Scale (NRS) as compared to 1 ms rectangular pulses (P < 0.05). Increasing the duration from 1 to 25 ms led to a 4-fold amplitude reduction for pain-thresholds and stimuli caused an axon-reflex flare. Excitability of single polymodal nociceptors in animals paralleled human psychophysics and we conclude optimized half-sine pulses facilitate C-nociceptor activation. - Perspective - Electrical stimulation with longer lasting half-sine wave pulses preferentially activates C-nociceptors and changes in the strength duration curve may identify nociceptor hyperexcitability in patients with neuropathic pain. |
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| DOI: | doi:10.1016/j.jpain.2023.01.009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jpain.2023.01.009 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1526590023000172 |
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| | DOI: https://doi.org/10.1016/j.jpain.2023.01.009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | C-nociceptor activation |
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| | chronaxie |
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| | current strength-duration |
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| | half-sine wave |
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| | rectangular pulse |
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| K10plus-PPN: | 1854657607 |
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| Verknüpfungen: | → Zeitschrift |
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Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers / Schneider, Tobias [VerfasserIn]; June 2023 (Online-Ressource)
