| |  Online-Ressource |
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| Verfasst von: | Tang, Chen [VerfasserIn]  |
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| | Unterrainer, Christian [VerfasserIn] |
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| | Fink, Annette [VerfasserIn] |
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| | Cinca, Sofia [VerfasserIn] |
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| | Ruhenstroth, Andrea [VerfasserIn] |
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| | Scherer, Sabine [VerfasserIn] |
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| | Morath, Christian [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Mehrabi, Arianeb [VerfasserIn] |
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| | Süsal, Caner [VerfasserIn] |
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| | Tran, Thuong Hien [VerfasserIn] |
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| Titel: | Analysis of de novo donor-specific HLA-DPB1 antibodies in kidney transplantation |
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| Verf.angabe: | Chen Tang, Christian Unterrainer, Annette Fink, Sofia Cinca, Andrea Ruhenstroth, Sabine Scherer, Christian Morath, Martin Zeier, Arianeb Mehrabi, Caner Süsal, Thuong Hien Tran |
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| Jahr: | 2021 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 08.08.2023 |
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| Titel Quelle: | Enthalten in: HLA |
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| Ort Quelle: | Oxford : Wiley, 2016 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 98(2021), 5, Seite 423-430 |
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| ISSN Quelle: | 2059-2310 |
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| Abstract: | HLA matching and avoidance of unacceptable mismatches are important aspects in the selection of donors for solid organ transplantation. The impact of HLA-DPB1 incompatibility on the outcomes of kidney transplantation is not fully understood. We investigated a potential effect of mismatching for HLA-DPB1 at allele, eplet, or Terasaki epitope (TerEp) level on the formation of de novo donor-specific antibodies (dnDSA) and also asked whether polymorphisms associated with HLA-DPB1 expression level may influence dnDSA induction. Furthermore, we analyzed the correlation between graft survival and HLA-DPB1 mismatches defined by different approaches. A cohort of 366 patients who received a kidney transplant at the Heidelberg University Hospital, Germany, with availability of pre- and post-transplant HLA antibody results by single antigen testing as well as of donor and recipient HLA-DPB1 high-resolution typing were analyzed retrospectively. Susceptibility to increased HLA-DPB1 expression was predicted by the linked dimorphism rs9277534 A/G of the HLA-DPB1 gene. Neither HLA-DPB1 mismatches at allele, eplet or TerEp level nor exposure to donor's high HLA-DPB1 expression were significantly associated with the risk of developing dnDSA against HLA-DPB1. However, HLA-DPB1 eplet and TerEp mismatches had a significant negative impact on graft survival (p < 0.001 and p = 0.003, respectively). Matching for HLA-DPB1 at epitope instead of allele level appears to have potential to improve graft survival in kidney transplantation. |
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| DOI: | doi:10.1111/tan.14422 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1111/tan.14422 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.14422 |
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| | DOI: https://doi.org/10.1111/tan.14422 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | de novo donor-specific antibodies |
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| | DSA |
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| | epitope |
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| | expression level |
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| | graft survival |
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| | HLA-DPB1 |
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| | kidney transplantation |
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| K10plus-PPN: | 1854789449 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Analysis of de novo donor-specific HLA-DPB1 antibodies in kidney transplantation / Tang, Chen [VerfasserIn]; 2021 (Online-Ressource)
