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Verfasst von:Amato, Carlo [VerfasserIn]   i
 Susenburger, Markus [VerfasserIn]   i
 Lehr, Samuel [VerfasserIn]   i
 Kuntz, Jan [VerfasserIn]   i
 Gehrke, Nicole [VerfasserIn]   i
 Franke, Danielle [VerfasserIn]   i
 Thüring, Thomas [VerfasserIn]   i
 Briel, Andreas [VerfasserIn]   i
 Brönnimann, Christian [VerfasserIn]   i
 Kachelrieß, Marc [VerfasserIn]   i
 Sawall, Stefan [VerfasserIn]   i
Titel:Dual-contrast photon-counting micro-CT using iodine and a novel bismuth-based contrast agent
Verf.angabe:Carlo Amato, Markus Susenburger, Samuel Lehr, Jan Kuntz, Nicole Gehrke, Danielle Franke, Thomas Thüring, Andreas Briel, Christian Brönnimann, Marc Kachelrieß and Stefan Sawall
Jahr:2023
Umfang:11 S.
Illustrationen:Illustrationen
Fussnoten:Veröffentlicht: 19. Juni 2023 ; Gesehen am 09.08.2023
Titel Quelle:Enthalten in: Physics in medicine and biology
Ort Quelle:Bristol : IOP Publ., 1956
Jahr Quelle:2023
Band/Heft Quelle:68(2023), 13, Artikel-ID 135001, Seite 1-11
ISSN Quelle:1361-6560
Abstract:Objectives. To characterize for the first time in vivo a novel bismuth-based nanoparticular contrast agent developed for preclinical applications. Then, to design and test in vivo a multi-contrast protocol for functional cardiac imaging using the new bismuth nanoparticles and a well-established iodine-based contrast agent. Approach. A micro-computed tomography scanner was assembled and equipped with a photon-counting detector. Five mice were administered with the bismuth-based contrast agent and systematically scanned over 5 h to quantify the contrast enhancement in relevant organs of interest. Subsequently, the multi-contrast agent protocol was tested on three mice. Material decomposition was performed on the acquired spectral data to quantify the concentration of bismuth and iodine in multiple structures, e.g. the myocardium and vasculature. Main results. In the vasculature, the bismuth agent provides a peak enhancement of 1100 HU and a half-life of about 260 min. After the injection, it accumulates in the liver, spleen and intestinal wall reaching a CT value of 440 HU about 5 h post injection. Phantom measurements showed that the bismuth provides more contrast enhancement than iodine for a variety of tube voltages. The multi-contrast protocol for cardiac imaging successfully allowed the simultaneous decomposition of the vasculature, the brown adipose tissue and the myocardium. Significance. The new bismuth-based contrast agent was proven to have a long circulation time suitable for preclinical applications and to provide more contrast than iodine agents. The proposed multi-contrast protocol resulted in a new tool for cardiac functional imaging. Furthermore, thanks to the contrast enhancement provided in the intestinal wall, the novel contrast agent may be used to develop further multi contrast agent protocols for abdominal and oncological imaging.
DOI:doi:10.1088/1361-6560/acdb42
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1088/1361-6560/acdb42
 Volltext: https://dx.doi.org/10.1088/1361-6560/acdb42
 DOI: https://doi.org/10.1088/1361-6560/acdb42
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1854986910
Verknüpfungen:→ Zeitschrift

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