| |  Online-Ressource |
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| Verfasst von: | Schaefer, Matthias R. [VerfasserIn]  |
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| | Pollex, Tim [VerfasserIn] |
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| | Hanna, Katharina [VerfasserIn] |
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| | Tuorto, Francesca [VerfasserIn] |
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| | Meusburger, Madeleine [VerfasserIn] |
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| | Helm, Mark [VerfasserIn] |
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| | Lyko, Frank [VerfasserIn] |
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| Titel: | RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage |
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| Verf.angabe: | Matthias Schaefer, Tim Pollex, Katharina Hanna, Francesca Tuorto, Madeleine Meusburger, Mark Helm and Frank Lyko |
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| Jahr: | 2010 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 10.08.2023 |
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| Titel Quelle: | Enthalten in: Genes & development |
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| Ort Quelle: | Stanford, Calif. : HighWire Press, 1987 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 24(2010), 15, Seite 1590-1595 |
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| ISSN Quelle: | 1549-5477 |
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| Abstract: | Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme family, but their substrate specificity and biological functions have been a subject of controversy. We show here that, in addition to tRNAAsp-GTC, tRNAVal-AAC and tRNAGly-GCC are also methylated by Dnmt2. Drosophila Dnmt2 mutants showed reduced viability under stress conditions, and Dnmt2 relocalized to stress granules following heat shock. Strikingly, stress-induced cleavage of tRNAs was Dnmt2-dependent, and Dnmt2-mediated methylation protected tRNAs against ribonuclease cleavage. These results uncover a novel biological function of Dnmt2-mediated tRNA methylation, and suggest a role for Dnmt2 enzymes during the biogenesis of tRNA-derived small RNAs. |
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| DOI: | doi:10.1101/gad.586710 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1101/gad.586710 |
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| | Volltext: http://genesdev.cshlp.org/content/24/15/1590 |
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| | DOI: https://doi.org/10.1101/gad.586710 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | angiogenin |
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| | Cytosine methylation |
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| | Dnmt2 |
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| | tRNA |
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| K10plus-PPN: | 1855085240 |
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| Verknüpfungen: | → Zeitschrift |
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RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage / Schaefer, Matthias R. [VerfasserIn]; 2010 (Online-Ressource)
