| |  Online-Ressource |
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| Verfasst von: | Jakob, Jens [VerfasserIn]  |
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| | Hentschel, Leopold [VerfasserIn] |
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| | Richter, Stephan [VerfasserIn] |
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| | Kreisel, Inga [VerfasserIn] |
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| | Hohenberger, Peter [VerfasserIn] |
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| | Kasper, Bernd [VerfasserIn] |
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| | Andreou, Dimosthenis [VerfasserIn] |
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| | Pink, Daniel [VerfasserIn] |
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| | Schmitt, Jochen [VerfasserIn] |
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| | Schuler, Markus K. [VerfasserIn] |
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| | Eichler, Martin [VerfasserIn] |
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| Titel: | Transferability of health-related quality of life data of large observational studies to clinical practice |
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| Titelzusatz: | comparing retroperitoneal sarcoma patients from the PROSa study to a TARPS-WG cohort |
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| Verf.angabe: | Jens Jakob, Leopold Hentschel, Stephan Richter, Inga Kreisel, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jochen Schmitt, Markus K. Schuler, Martin Eichler |
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| E-Jahr: | 2022 |
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| Jahr: | June 14 2022 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 14.08.2023 |
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| Titel Quelle: | Enthalten in: Oncology research and treatment |
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| Ort Quelle: | Basel : Karger, 2014 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 45(2022), 11 vom: Okt., Seite 660-668 |
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| ISSN Quelle: | 2296-5262 |
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| Abstract: | Introduction: Health-related quality of life (HRQoL) is crucial for shared decision-making. The “Patient-Reported Outcome measures in Sarcoma” (PROSa) study evaluated HRQoL in general. We evaluated the transferability of PROSa data to clinical practice for the subgroup of retroperitoneal sarcoma (RPS). Methods: To obtain a PROSa-RPS cohort, we excluded patients with bone sarcomas and gastrointestinal stromal tumors from the complete PROSa cohort (n = 1,113), limited tumor localization to trunk and retroperitoneum, and excluded patients with metastases. We evaluated the HRQoL data of the resulting 76 patients and compared their clinical data to those of the Transatlantic Autralasian Retroperitoneal Sarcoma Working Group (TARPS-WG, n = 1,007). Results: Confidence intervals for patient sex, histological subtype (LPS vs. non-LPS), grading (G1 vs. G2/3), surgical margins (R2 vs. no R2), and perioperative chemo- and radiotherapy (yes vs. no) were overlapping in both cohorts. EORTC QLQ-C30 from RPS-PROSa patients demonstrated that two-thirds had clinically relevant restrictions in physical functioning. Two-thirds reported dyspnea, followed by fatigue and pain. Conclusion: Clinical data from RPS-PROSa patients are comparable to those of an RPS reference cohort from expert centers. We believe that HRQoL data of RPS patients extracted from PROSa are transferable to clinical practice. |
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| DOI: | doi:10.1159/000525288 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000525288 |
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| | Volltext: https://karger.com/ort/article/45/11/660/821090/Transferability-of-Health-Related-Quality-of-Life |
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| | DOI: https://doi.org/10.1159/000525288 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1856087573 |
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| Verknüpfungen: | → Zeitschrift |
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Transferability of health-related quality of life data of large observational studies to clinical practice / Jakob, Jens [VerfasserIn]; June 14 2022 (Online-Ressource)
