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| Verfasst von: | Pérez-Cervera, Laura [VerfasserIn]  |
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| | De Santis, Silvia [VerfasserIn] |
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| | Marcos, Encarni [VerfasserIn] |
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| | Ghorbanzad-Ghaziany, Zahra [VerfasserIn] |
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| | Trouvé-Carpena, Alejandro [VerfasserIn] |
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| | Selim, Mohamed Kotb [VerfasserIn] |
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| | Pérez-Ramírez, Úrsula [VerfasserIn] |
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| | Pfarr, Simone [VerfasserIn] |
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| | Bach, Patrick [VerfasserIn] |
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| | Halli, Patrick [VerfasserIn] |
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| | Kiefer, Falk [VerfasserIn] |
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| | Moratal, David [VerfasserIn] |
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| | Kirsch, Peter [VerfasserIn] |
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| | Sommer, Wolfgang H. [VerfasserIn] |
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| | Canals, Santiago [VerfasserIn] |
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| Titel: | Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence |
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| Verf.angabe: | Laura Pérez-Cervera, Silvia De Santis, Encarni Marcos, Zahra Ghorbanzad-Ghaziany, Alejandro Trouvé-Carpena, Mohamed Kotb Selim, Úrsula Pérez-Ramírez, Simone Pfarr, Patrick Bach, Patrick Halli, Falk Kiefer, David Moratal, Peter Kirsch, Wolfgang H. Sommer and Santiago Canals |
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| Jahr: | 2023 |
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| Umfang: | 21 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Veröffentlicht: 21. Juni 2023 ; Gesehen am 14.08.2023 |
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| Titel Quelle: | Enthalten in: Acta Neuropathologica Communications |
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| Ort Quelle: | London : Biomed Central, 2013 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 11(2023), Artikel-ID 101, Seite 1-21 |
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| ISSN Quelle: | 2051-5960 |
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| Abstract: | Alcohol dependence is characterized by a gradual reduction in cognitive control and inflexibility to contingency changes. The neuroadaptations underlying this aberrant behavior are poorly understood. Using an animal model of alcohol use disorders (AUD) and complementing diffusion-weighted (dw)-MRI with quantitative immunohistochemistry and electrophysiological recordings, we provide causal evidence that chronic intermittent alcohol exposure affects the microstructural integrity of the fimbria/fornix, decreasing myelin basic protein content, and reducing the effective communication from the hippocampus (HC) to the prefrontal cortex (PFC). Using a simple quantitative neural network model, we show how disturbed HC-PFC communication may impede the extinction of maladaptive memories, decreasing flexibility. Finally, combining dw-MRI and psychometric data in AUD patients, we discovered an association between the magnitude of microstructural alteration in the fimbria/fornix and the reduction in cognitive flexibility. Overall, these findings highlight the vulnerability of the fimbria/fornix microstructure in AUD and its potential contribution to alcohol pathophysiology. |
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| DOI: | doi:10.1186/s40478-023-01597-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s40478-023-01597-8 |
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| | DOI: https://doi.org/10.1186/s40478-023-01597-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alcohol |
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| | AUD |
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| | Cognitive test |
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| | Diffusion |
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| | DTI |
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| | Fimbria |
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| | Flexibility |
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| | Fornix |
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| | Hippocampus |
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| | Memory |
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| | Prefrontal cortex |
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| | TMT |
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| | White matter |
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| K10plus-PPN: | 1856087921 |
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| Verknüpfungen: | → Zeitschrift |
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Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence / Pérez-Cervera, Laura [VerfasserIn]; 2023 (Online-Ressource)
