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Status: Bibliographieeintrag

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Verfasst von:Schaarschmidt, Benedikt Michael Sebastian [VerfasserIn]   i
 Kloeckner, Roman [VerfasserIn]   i
 Dertnig, Thomas [VerfasserIn]   i
 Demircioglu, Aydin [VerfasserIn]   i
 Müller, Lukas [VerfasserIn]   i
 Auer, Timo Alexander [VerfasserIn]   i
 Santos, Daniel Pinto dos [VerfasserIn]   i
 Wagner, Verena [VerfasserIn]   i
 Miederer, Matthias [VerfasserIn]   i
 Gebauer, Bernhard [VerfasserIn]   i
 Radunz, Sonia [VerfasserIn]   i
 Kasper, Stefan [VerfasserIn]   i
 Weber, Manuel [VerfasserIn]   i
 Theysohn, Jens [VerfasserIn]   i
Titel:Real-life experience in the treatment of intrahepatic cholangiocarcinoma by 90Y radioembolization
Titelzusatz:a multicenter retrospective study
Verf.angabe:Benedikt M. Schaarschmidt, Roman Kloeckner, Thomas Dertnig, Aydin Demircioglu, Lukas Müller, Timo Alexander Auer, Daniel Pinto dos Santos, Verena Steinle, Matthias Miederer, Bernhard Gebauer, Sonia Radunz, Stefan Kasper, Manuel Weber and Jens Theysohn
E-Jahr:2023
Jahr:April 1, 2023
Umfang:7 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 3. November 2022 ; Im Titel ist die Zahl 90 hochgestellt ; Gesehen am 15.08.2023
Titel Quelle:Enthalten in: Journal of nuclear medicine
Ort Quelle:New York, NY : Soc., 1964
Jahr Quelle:2023
Band/Heft Quelle:64(2023), 4 vom: Apr., Seite 529-535
ISSN Quelle:2159-662X
 1535-5667
Abstract:Limited treatment options in patients with intrahepatic cholangiocarcinoma (iCCA) demand the introduction of new, catheter-based treatment options. Especially, 90Y radioembolization may expand therapeutic abilities beyond surgery or chemotherapy. Therefore, the purpose of this study was to identify factors associated with an improved median overall survival (mOS) in iCCA patients receiving radioembolization in a retrospective study at 5 major tertiary-care centers. Methods: In total, 138 radioembolizations in 128 patients with iCCA (female, 47.7%; male, 52.3%; mean age ± SD, 61.1 ± 13.4 y) were analyzed. Clinical data, imaging characteristics, and radioembolization reports, as well as data from RECIST, version 1.1, analysis performed 3, 6, and 12 mo after radioembolization, were collected. mOS was compared among different subgroups using Kaplan–Meier curves and the log-rank test. Results: Radioembolization was performed as first-line treatment in 25.4%, as second-line treatment in 38.4%, and as salvage treatment in 36.2%. In patients receiving first-line, second-line, and salvage radioembolization, the disease control rate was 68.6%, 52.8%, and 54.0% after 3 mo; 31.4%, 15.1%, and 12.0% after 6 mo; and 17.1%, 5.7%, and 6.0% after 1 y, respectively. In patients receiving radioembolization as first-line, second-line, and salvage treatment, mOS was 12.0 mo (95% CI, 7.6–23.4 mo), 11.8 mo (95% CI, 9.1–16.6 mo), and 8.4 mo (95% CI, 6.3–12.7 mo), respectively. No significant differences among the 3 groups were observed (P = 0.15). Hepatic tumor burden did not significantly influence mOS (P = 0.12). Conclusion: Especially in advanced iCCA, second-line and salvage radioembolization may be important treatment options. In addition to ongoing studies investigating the role of radioembolization as first-line treatment, the role of radioembolization in the later treatment stages of the disease demands further attention.
DOI:doi:10.2967/jnumed.122.264598
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.2967/jnumed.122.264598
 Volltext: https://jnm.snmjournals.org/content/64/4/529
 DOI: https://doi.org/10.2967/jnumed.122.264598
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:CCA
 cholangiocarcinoma
 radioembolization
 SIRT
 TARE
K10plus-PPN:1856186970
Verknüpfungen:→ Zeitschrift

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