Fatal chloroquine intoxication

• Verfasst von: Keller, Thomas [VerfasserIn]
• Verfasst von: Schneider, Andrea [VerfasserIn]
• Verfasst von: Lamprecht, Robert [VerfasserIn]
• Verfasst von: Aderjan, Rolf [VerfasserIn]
• Verfasst von: Tutsch-Bauer, Edith [VerfasserIn]
• Verfasst von: Kisser, Wolfgang [VerfasserIn]
• Titel: Fatal chloroquine intoxication
• Verf.angabe: Thomas Keller, Andrea Schneider, Robert Lamprecht, Rolf Aderjan, Edith Tutsch-Bauer, Wolfgang Kisser
• E-Jahr: 1998
• Jahr: 21 September 1998
• Umfang: 8 S.
• Fussnoten: Gesehen am 15.08.2023
• Titel Quelle: Enthalten in: Forensic science international
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1978
• Jahr Quelle: 1998
• Band/Heft Quelle: 96(1998), 1, Seite 21-28
• ISSN Quelle: 1872-6283
• DOI: doi:10.1016/S0379-0738(98)00105-4
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Chloroquine
• Sach-SW: GC/MS
• Sach-SW: Overdose
• Sach-SW: Poison
• Sach-SW: Resochin®
• Sach-SW: Suicide
• Sach-SW: Toxicology
• K10plus-PPN: 1856194507

Abstract

A suicidal ingestion of an unknown quantity of Resochin® (chloroquine) tablets is described. Although chloroquine is known since 1934, intoxications due to chloroquine overdose are rather rare in European countries. The authors report on a new and fast method of analysing and determining the chloroquine concentration in body fluids and postmortem specimens. The analytes were extracted from alkalinized samples into ethyl acetate before GC/MS analysis. The analyses of chloroquine were performed without any complex sample clean-up steps and, in addition, with little sample material. The proposed method resulted in a rapid procedure most useful in cases of deliberate poisoning with the anti-inflammatory and antimalarial drug chloroquine.