| |  Online-Ressource |
|---|
| Verfasst von: | Dittrich, Gesine M. [VerfasserIn]  |
|---|
| | Froese, Natali [VerfasserIn] |
|---|
| | Wang, Xue [VerfasserIn] |
|---|
| | Kroeger, Hannah [VerfasserIn] |
|---|
| | Wang, Honghui [VerfasserIn] |
|---|
| | Szaroszyk, Malgorzata [VerfasserIn] |
|---|
| | Malek Mohammadi, Mona [VerfasserIn] |
|---|
| | Cordero Henriquez, Julio Domingo [VerfasserIn] |
|---|
| | Keles, Merve [VerfasserIn] |
|---|
| | Korf-Klingebiel, Mortimer [VerfasserIn] |
|---|
| | Wollert, Kai C. [VerfasserIn] |
|---|
| | Geffers, Robert [VerfasserIn] |
|---|
| | Mayr, Manuel [VerfasserIn] |
|---|
| | Conway, Simon J. [VerfasserIn] |
|---|
| | Dobreva, Gergana [VerfasserIn] |
|---|
| | Bauersachs, Johann [VerfasserIn] |
|---|
| | Heineke, Jörg [VerfasserIn] |
|---|
| Titel: | Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis |
|---|
| Verf.angabe: | Gesine M.Dittrich, Natali Froese, Xue Wang, Hannah Kroeger, Honghui Wang, Malgorzata Szaroszyk, Mona Malek-Mohammadi, Julio Cordero, Merve Keles, Mortimer Korf-Klingebiel, Kai C.Wollert, Robert Geffers, Manuel Mayr, Simon J.Conway, Gergana Dobreva, Johann Bauersachs, Joerg Heineke |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | 19 April 2021 |
|---|
| Umfang: | 19 S. |
|---|
| Fussnoten: | Gesehen am 15.08.2023 |
|---|
| Titel Quelle: | Enthalten in: Basic research in cardiology |
|---|
| Ort Quelle: | [Darmstadt u.a.] : Steinkopff, 1937 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 116(2021), Artikel-ID 26, Seite 1-19 |
|---|
| ISSN Quelle: | 1435-1803 |
|---|
| Abstract: | Heart failure due to high blood pressure or ischemic injury remains a major problem for millions of patients worldwide. Despite enormous advances in deciphering the molecular mechanisms underlying heart failure progression, the cell-type specific adaptations and especially intercellular signaling remain poorly understood. Cardiac fibroblasts express high levels of cardiogenic transcription factors such as GATA-4 and GATA-6, but their role in fibroblasts during stress is not known. Here, we show that fibroblast GATA-4 and GATA-6 promote adaptive remodeling in pressure overload induced cardiac hypertrophy. Using a mouse model with specific single or double deletion of Gata4 and Gata6 in stress activated fibroblasts, we found a reduced myocardial capillarization in mice with Gata4/6 double deletion following pressure overload, while single deletion of Gata4 or Gata6 had no effect. Importantly, we confirmed the reduced angiogenic response using an in vitro co-culture system with Gata4/6 deleted cardiac fibroblasts and endothelial cells. A comprehensive RNA-sequencing analysis revealed an upregulation of anti-angiogenic genes upon Gata4/6 deletion in fibroblasts, and siRNA mediated downregulation of these genes restored endothelial cell growth. In conclusion, we identified a novel role for the cardiogenic transcription factors GATA-4 and GATA-6 in heart fibroblasts, where both proteins act in concert to promote myocardial capillarization and heart function by directing intercellular crosstalk. |
|---|
| DOI: | doi:10.1007/s00395-021-00862-y |
|---|
| URL: | kostenfrei: Volltext: https://doi.org/10.1007/s00395-021-00862-y |
|---|
| | kostenfrei: Volltext: https://link.springer.com/10.1007/s00395-021-00862-y |
|---|
| | DOI: https://doi.org/10.1007/s00395-021-00862-y |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1856238113 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
| |
|
|---|
| | |
|---|
| Lokale URL UB: |  Zum Volltext |
|---|
Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis / Dittrich, Gesine M. [VerfasserIn]; 19 April 2021 (Online-Ressource)
