Immunocytochemical correlation of peptides and tyrosine hydroxylase in nerve fibres of the human parotid gland

• Verfasst von: Heym, Christine [VerfasserIn]
• Verfasst von: Webber, Richard [VerfasserIn]
• Verfasst von: Adler, Detlev [VerfasserIn]
• Titel: Immunocytochemical correlation of peptides and tyrosine hydroxylase in nerve fibres of the human parotid gland
• Verf.angabe: Christine Heym, Richard Webber, Detlef Adler
• Jahr: 1994
• Umfang: 9 S.
• Fussnoten: Falsche Namensform: richtig Detlev Adler ; Elektronische Reproduktion der Druck-Ausgabe 8. März 2004 ; Gesehen am 16.08.2023
• Titel Quelle: Enthalten in: Archives of oral biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1959
• Jahr Quelle: 1994
• Band/Heft Quelle: 39(1994), 3, Seite 213-221
• ISSN Quelle: 1879-1506
• DOI: doi:10.1016/0003-9969(94)90047-7
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: autonomic innervation
• Sach-SW: man
• Sach-SW: neuropeptides
• Sach-SW: salivary glands
• K10plus-PPN: 1856308340

Abstract

The peptidergic innervation of parenchymal and vascular components in the human parotid gland was investigated by double-labelling fluorescence. Peptide immunoreactivity in nerve fibres was correlated with the presence of tyrosine hydroxylase (TH). By light microscopy, acinar innervation consisted of fibres with the combinations neuropeptide Y (NPY)/TH and NPY/vasoactive intestinal polypeptide (VIP). Some fibres were solely NPY, TH or VIP immunoreactive. Rarely, substance P (SP)/calcitonin gene-related (CGRP)-immunolabelled fibres were associated with acini. Intercalated ducts were often approached by NPY/TH- and VIP-containing fibres. VIP innervation of excretory ducts was sparse. Intralobular and intralobar excretory ducts, in addition to NPY and TH, revealed CGRP and CGRP/SP innervation, whereas nerve fibres on interlobar excretory ducts very rarely contained NPY and none of the other mediators. Vascular innervation consisted of NPY/TH and SP/CGRP fibres; in a few fibres SP was colocalized with leu-enkephalin. Large arteries were encircled by some VIP-positive fibres. The findings suggest a specific participation of neuropeptides and of peptide combinations in the regulation of parotid exocrine function.