SUMO

• Verfasst von: Melchior, Frauke [VerfasserIn]
• Verfasst von: Schergaut, Marion [VerfasserIn]
• Verfasst von: Pichler, Andrea [VerfasserIn]
• Titel: SUMO
• Titelzusatz: ligases, isopeptidases and nuclear pores
• Verf.angabe: Frauke Melchior, Marion Schergaut, Andrea Pichler
• E-Jahr: 2003
• Jahr: November 2003
• Umfang: 7 S.
• Fussnoten: Gesehen am 17.08.2023
• Titel Quelle: Enthalten in: Trends in biochemical sciences
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1976
• Jahr Quelle: 2003
• Band/Heft Quelle: 28(2003), 11 vom: Nov., Seite 612-618
• ISSN Quelle: 1362-4326
• DOI: doi:10.1016/j.tibs.2003.09.002
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1856450937

Abstract

Small ubiquitin-related modifier (SUMO) proteins are reversibly coupled to numerous intracellular targets and modulate their interactions, localization, activity or stability. Recent advances in the SUMO field have uncovered the first SUMO E3 ligases and point to a complex family of isopeptidases. SUMO has been linked to many different pathways, including nucleocytoplasmic transport. Modifying enzymes and an isopeptidase have been detected at nuclear pore complexes. In addition, studies in yeast suggest a requirement of SUMO conjugation for nuclear protein import, and specific SUMO targets depend on modification for nuclear import or export.