| |  Online-Ressource |
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| Verfasst von: | Alfaro Nunez, Ana Jimena [VerfasserIn]  |
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| | Dittner, Claudia [VerfasserIn] |
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| | Becker, Janina [VerfasserIn] |
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| | Loft, Anne [VerfasserIn] |
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| | Mhamane, Amit [VerfasserIn] |
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| | Maida, Adriano [VerfasserIn] |
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| | Georgiadi, Anastasia [VerfasserIn] |
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| | Tsokanos, Foivos Filippos [VerfasserIn] |
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| | Klepac, Katarina [VerfasserIn] |
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| | Molocea, Claudia-Eveline [VerfasserIn] |
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| | El Merahbi, Rabih [VerfasserIn] |
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| | Motzler, Karsten [VerfasserIn] |
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| | Geppert, Julia [VerfasserIn] |
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| | Karikari, Rhoda Anane [VerfasserIn] |
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| | Szendrödi, Julia [VerfasserIn] |
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| | Feuchtinger, Annette [VerfasserIn] |
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| | Hofmann, Susanna [VerfasserIn] |
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| | Karaca, Samir [VerfasserIn] |
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| | Urlaub, Henning [VerfasserIn] |
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| | Berriel Diaz, Mauricio [VerfasserIn] |
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| | Melchior, Frauke [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| Titel: | Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism |
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| Verf.angabe: | Ana Jimena Alfaro, Claudia Dittner, Janina Becker, Anne Loft, Amit Mhamane, Adriano Maida, Anastasia Georgiadi, Foivos-Filippos Tsokanos, Katarina Klepac, Claudia-Eveline Molocea, Rabih El-Merahbi, Karsten Motzler, Julia Geppert, Rhoda Anane Karikari, Julia Szendrödi, Annette Feuchtinger, Susanna Hofmann, Samir Karaca, Henning Urlaub, Mauricio Berriel Diaz, Frauke Melchior & Stephan Herzig |
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| E-Jahr: | 2023 |
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| Jahr: | 10 August 2023 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 17.08.2023 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO reports |
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| Ort Quelle: | Heidelberg : EMBO Press, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | (2023), Artikel-ID e55981, Seite 1-18 |
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| ISSN Quelle: | 1469-3178 |
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| Abstract: | Abstract Accumulation of excess nutrients hampers proper liver function and is linked to nonalcoholic fatty liver disease (NAFLD) in obesity. However, the signals responsible for an impaired adaptation of hepatocytes to obesogenic dietary cues remain still largely unknown. Post-translational modification by the small ubiquitin-like modifier (SUMO) allows for a dynamic regulation of numerous processes including transcriptional reprogramming. We demonstrate that specific SUMOylation of transcription factor Prox1 represents a nutrient-sensitive determinant of hepatic fasting metabolism. Prox1 is highly SUMOylated on lysine 556 in the liver of ad libitum and refed mice, while this modification is abolished upon fasting. In the context of diet-induced obesity, Prox1 SUMOylation becomes less sensitive to fasting cues. The hepatocyte-selective knock-in of a SUMOylation-deficient Prox1 mutant into mice fed a high-fat/high-fructose diet leads to a reduction of systemic cholesterol levels, associated with the induction of liver bile acid detoxifying pathways during fasting. The generation of tools to maintain the nutrient-sensitive SUMO-switch on Prox1 may thus contribute to the development of ?fasting-based? approaches for the preservation of metabolic health. |
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| DOI: | doi:10.15252/embr.202255981 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.15252/embr.202255981 |
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| | Volltext: https://www.embopress.org/doi/full/10.15252/embr.202255981 |
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| | DOI: https://doi.org/10.15252/embr.202255981 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bile acids |
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| | Cholesterol |
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| | Liver |
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| | Prox1 |
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| | SUMOylation |
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| K10plus-PPN: | 1856456579 |
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| Verknüpfungen: | → Zeitschrift |
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Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism / Alfaro Nunez, Ana Jimena [VerfasserIn]; 10 August 2023 (Online-Ressource)
