Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Pfeffer, Tilman [VerfasserIn]   i
 Wetzel, Charlotte [VerfasserIn]   i
 Kirschner, Philip [VerfasserIn]   i
 Bartosova, Maria [VerfasserIn]   i
 Poth, Tanja [VerfasserIn]   i
 Schwab, Constantin [VerfasserIn]   i
 Poschet, Gernot [VerfasserIn]   i
 Zemva, Johanna [VerfasserIn]   i
 Bulkescher, Ruben [VerfasserIn]   i
 Damgov, Ivan [VerfasserIn]   i
 Thiel, Christian [VerfasserIn]   i
 Garbade, Sven [VerfasserIn]   i
 Klingbeil, Kristina [VerfasserIn]   i
 Peters, Verena [VerfasserIn]   i
 Schmitt, Claus P. [VerfasserIn]   i
Titel:Carnosinase-1 knock-out reduces kidney fibrosis in type-1 diabetic mice on high fat diet
Verf.angabe:Tilman Pfeffer, Charlotte Wetzel, Philip Kirschner, Maria Bartosova, Tanja Poth, Constantin Schwab, Gernot Poschet, Johanna Zemva, Ruben Bulkescher, Ivan Damgov, Christian Thiel, Sven F. Garbade, Kristina Klingbeil, Verena Peters and Claus Peter Schmitt
E-Jahr:2023
Jahr:14 June 2023
Umfang:15 S.
Fussnoten:Gesehen am 18.08.2023
Titel Quelle:Enthalten in: Antioxidants
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2023
Band/Heft Quelle:12(2023), 6, Artikel-ID 1270, Seite 1-15
ISSN Quelle:2076-3921
Abstract:Carnosine and anserine supplementation markedLy reduce diabetic nephropathy in rodents. The mode of nephroprotective action of both dipeptides in diabetes, via local protection or improved systemic glucose homeostasis, is uncertain. Global carnosinase-1 knockout mice (Cndp1-KO) and wild-type littermates (WT) on a normal diet (ND) and high fat diet (HFD) (n = 10/group), with streptozocin (STZ)-induced type-1 diabetes (n = 21-23/group), were studied for 32 weeks. Independent of diet, Cndp1-KO mice had 2- to 10-fold higher kidney anserine and carnosine concentrations than WT mice, but otherwise a similar kidney metabolome; heart, liver, muscle and serum anserine and carnosine concentrations were not different. Diabetic Cndp1-KO mice did not differ from diabetic WT mice in energy intake, body weight gain, blood glucose, HbA1c, insulin and glucose tolerance with both diets, whereas the diabetes-related increase in kidney advanced glycation end-product and 4-hydroxynonenal concentrations was prevented in the KO mice. Tubular protein accumulation was lower in diabetic ND and HFD Cndp1-KO mice, interstitial inflammation and fibrosis were lower in diabetic HFD Cndp1-KO mice compared to diabetic WT mice. Fatalities occurred later in diabetic ND Cndp1-KO mice versus WT littermates. Independent of systemic glucose homeostasis, increased kidney anserine and carnosine concentrations reduce local glycation and oxidative stress in type-1 diabetic mice, and mitigate interstitial nephropathy in type-1 diabetic mice on HFD.
DOI:doi:10.3390/antiox12061270
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/antiox12061270
 Volltext: https://www.mdpi.com/2076-3921/12/6/1270
 DOI: https://doi.org/10.3390/antiox12061270
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:anserine
 carnosine
 diabetic nephropathy
 fibrosis
K10plus-PPN:1856512185
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69113879   QR-Code
zum Seitenanfang