Transient global amnesia with unexpected clinical and radiological findings

• Verfasst von: Piffer, Silvio [VerfasserIn]
• Verfasst von: Nannoni, Stefania [VerfasserIn]
• Verfasst von: Maulucci, Francesco [VerfasserIn]
• Verfasst von: Beaud, Valérie [VerfasserIn]
• Verfasst von: Rouaud, Olivier [VerfasserIn]
• Verfasst von: Förster, Alex [VerfasserIn]
• Verfasst von: Cereda, Carlo W. [VerfasserIn]
• Verfasst von: Maeder, Philippe [VerfasserIn]
• Verfasst von: Michel, Patrik [VerfasserIn]
• Titel: Transient global amnesia with unexpected clinical and radiological findings
• Titelzusatz: a case series and systematic review
• Verf.angabe: Silvio Piffer, Stefania Nannoni, Francesco Maulucci, Valérie Beaud, Olivier Rouaud, Alex Förster, Carlo W. Cereda, Philippe Maeder, Patrik Michel
• E-Jahr: 2022
• Jahr: 15 October 2022
• Umfang: 7 S.
• Fussnoten: Online verfügbar: 23 July 2022, Artikelversion: 6 August 2022 ; Gesehen am 22.08.2023
• Titel Quelle: Enthalten in: Journal of the neurological sciences
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1964
• Jahr Quelle: 2022
• Band/Heft Quelle: 441(2022) vom: Okt., Artikel-ID 120349, Seite 1-7
• ISSN Quelle: 1878-5883
• DOI: doi:10.1016/j.jns.2022.120349
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Amnesia
• Sach-SW: Atypical transient global amnesia
• Sach-SW: Hippocampal punctate diffusion lesion
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Transient global amnesia
• K10plus-PPN: 1856827453

Abstract

Background - Transient global amnesia (TGA) represents a benign neurological syndrome of unknown pathophysiology, often accompanied by vanishing hippocampal punctate diffusion-weighted imaging lesions (HPDL). The literature suggests that TGA may present with unusual features. This study analyses atypical clinical and radiological manifestations of patients with TGA and/or HPDL. - Methods - We retrospectively reviewed patients with atypical clinical or radiological presentations of TGA and/or HPDL in three neurology centers. We also performed a systematic review of literature using predefined search terms. Results were classified as: A) Atypical clinical manifestations of TGA (such as amnesia with additional manifestations, or only non-amnesic manifestations); B) Atypical radiological manifestations of clinically typical TGA. - Results - We identified 83 patients: 18 in our centres (median age 63.5years, 39% female) and 65 in the literature. In group A, 43 patients presented atypical clinical manifestations such as TGA with added transitory cognitive or sensory-motor deficits, seizures, headaches, but also non-amnesic presentations associated with HPDL and incidental HPDL without symptoms. In group B, 40 patients with typical clinical TGA showed extra-hippocampal punctate diffusion lesions (E-HPDL) which disappeared on follow-up imaging. Using clinical and radiological manifestations, we classified these patients into different categories describing a “TGA-PDL spectrum”. - Conclusions - TGA may have atypical clinical manifestations despite typical neuroimaging and patients with typical TGA may show vanishing extra-hippocampal punctate diffusion lesions. TGA, related clinical manifestations, and vanishing punctate diffusion lesions should be considered part of a larger “TGA-PDL spectrum”, allowing for better diagnosis of typical and atypical cases and stimulating further studies.