| Online-Ressource |
Verfasst von: | Requena, Gema [VerfasserIn]  |
| Czira, Alexandrosz [VerfasserIn]  |
| Banks, Victoria [VerfasserIn]  |
| Wood, Robert [VerfasserIn]  |
| Tritton, Theo [VerfasserIn]  |
| Castillo, Catherine M. [VerfasserIn]  |
| Yeap, Jie [VerfasserIn]  |
| Wild, Rosie [VerfasserIn]  |
| Compton, Chris [VerfasserIn]  |
| Rothnie, Kieran J. [VerfasserIn]  |
| Herth, Felix [VerfasserIn]  |
| Quint, Jennifer K. [VerfasserIn]  |
| Ismaila, Afisi S. [VerfasserIn]  |
Titel: | Comparison of rescue medication prescriptions in patients with chronic obstructive pulmonary disease receiving umeclidinium/vilanterol versus tiotropium bromide/olodaterol in routine clinical practice in England |
Verf.angabe: | Gema Requena, Alexandrosz Czira, Victoria Banks, Robert Wood, Theo Tritton, Catherine M. Castillo, Jie Yeap, Rosie Wild, Chris Compton, Kieran J. Rothnie, Felix Herth, Jennifer K. Quint, Afisi S. Ismaila |
Jahr: | 2023 |
Umfang: | 14 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Veröffentlicht: 13. Juli 2023 ; Gesehen am 22.08.2023 |
Titel Quelle: | Enthalten in: The International journal of chronic obstructive pulmonary disease |
Ort Quelle: | Albany, Auckland : DOVE Medical Press, 2006 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 18(2023), Seite 1431-1444 |
ISSN Quelle: | 1178-2005 |
Abstract: | Purpose: Routinely collected healthcare data on the comparative effectiveness of the long-acting muscarinic antagonist/long-acting β2-agonist combination umeclidinium/vilanterol (UMEC/VI) versus tiotropium bromide/olodaterol (TIO/OLO) for chronic obstructive pulmonary disease (COPD) is limited. This study compared rescue medication prescriptions in patients with COPD in England receiving UMEC/VI versus TIO/OLO. Patients and Methods: This retrospective cohort study used primary care data from the Clinical Practice Research Datalink Aurum database linked with secondary care administrative data from Hospital Episode Statistics. Patients with a COPD diagnosis at age ≥ 35 years were included (indexed) following initiation of single-inhaler UMEC/VI or TIO/OLO between July 1, 2015, and September 30, 2019. Outcomes included the number of rescue medication prescriptions at 12-months (primary), and at 6-, 18- and 24-months (secondary), adherence at 6-, 12-, 18- and 24-months post-index, defined as proportion of days covered ≥ 80% (secondary), and time-to-initiation of triple therapy (exploratory). Inverse probability of treatment weighting (IPTW) was used to balance potential confounding baseline characteristics. Superiority of UMEC/VI versus TIO/OLO for the primary outcome of rescue medication prescriptions was assessed using an intention-to-treat analysis with a p-value < 0.05. Results: In total, 8603 patients were eligible (UMEC/VI: n = 6536; TIO/OLO: n = 2067). Following IPTW, covariates were well balanced across groups. Patients initiating UMEC/VI had statistically significantly fewer (mean [standard deviation]; p-value) rescue medication prescriptions versus TIO/OLO in both the unweighted (4.84 [4.78] vs 5.68 [5.00]; p < 0.001) and weighted comparison (4.91 [4.81] vs 5.48 [5.02]; p = 0.0032) at 12 months; consistent results were seen at all timepoints. Adherence was numerically higher for TIO/OLO versus UMEC/VI at all timepoints. Time-to-triple therapy was similar between treatment groups. Conclusion: UMEC/VI was superior to TIO/OLO in reducing rescue medication prescriptions at 12 months after treatment initiation in a primary care cohort in England, potentially suggesting improvements in symptom control with UMEC/VI compared with TIO/OLO. |
DOI: | doi:10.2147/COPD.S411437 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.2147/COPD.S411437 |
| kostenfrei: Volltext: https://www.dovepress.com/comparison-of-rescue-medication-prescriptions-in-patients-with-chronic-peer-reviewed-fulltext- ... |
| DOI: https://doi.org/10.2147/COPD.S411437 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1857223276 |
Verknüpfungen: | → Zeitschrift |
Comparison of rescue medication prescriptions in patients with chronic obstructive pulmonary disease receiving umeclidinium/vilanterol versus tiotropium bromide/olodaterol in routine clinical practice in England / Requena, Gema [VerfasserIn]; 2023 (Online-Ressource)