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Verfasst von:Requena, Gema [VerfasserIn]   i
 Czira, Alexandrosz [VerfasserIn]   i
 Banks, Victoria [VerfasserIn]   i
 Wood, Robert [VerfasserIn]   i
 Tritton, Theo [VerfasserIn]   i
 Castillo, Catherine M. [VerfasserIn]   i
 Yeap, Jie [VerfasserIn]   i
 Wild, Rosie [VerfasserIn]   i
 Compton, Chris [VerfasserIn]   i
 Rothnie, Kieran J. [VerfasserIn]   i
 Herth, Felix [VerfasserIn]   i
 Quint, Jennifer K. [VerfasserIn]   i
 Ismaila, Afisi S. [VerfasserIn]   i
Titel:Comparison of rescue medication prescriptions in patients with chronic obstructive pulmonary disease receiving umeclidinium/vilanterol versus tiotropium bromide/olodaterol in routine clinical practice in England
Verf.angabe:Gema Requena, Alexandrosz Czira, Victoria Banks, Robert Wood, Theo Tritton, Catherine M. Castillo, Jie Yeap, Rosie Wild, Chris Compton, Kieran J. Rothnie, Felix Herth, Jennifer K. Quint, Afisi S. Ismaila
Jahr:2023
Umfang:14 S.
Illustrationen:Illustrationen
Fussnoten:Veröffentlicht: 13. Juli 2023 ; Gesehen am 22.08.2023
Titel Quelle:Enthalten in: The International journal of chronic obstructive pulmonary disease
Ort Quelle:Albany, Auckland : DOVE Medical Press, 2006
Jahr Quelle:2023
Band/Heft Quelle:18(2023), Seite 1431-1444
ISSN Quelle:1178-2005
Abstract:Purpose: Routinely collected healthcare data on the comparative effectiveness of the long-acting muscarinic antagonist/long-acting β2-agonist combination umeclidinium/vilanterol (UMEC/VI) versus tiotropium bromide/olodaterol (TIO/OLO) for chronic obstructive pulmonary disease (COPD) is limited. This study compared rescue medication prescriptions in patients with COPD in England receiving UMEC/VI versus TIO/OLO. Patients and Methods: This retrospective cohort study used primary care data from the Clinical Practice Research Datalink Aurum database linked with secondary care administrative data from Hospital Episode Statistics. Patients with a COPD diagnosis at age ≥ 35 years were included (indexed) following initiation of single-inhaler UMEC/VI or TIO/OLO between July 1, 2015, and September 30, 2019. Outcomes included the number of rescue medication prescriptions at 12-months (primary), and at 6-, 18- and 24-months (secondary), adherence at 6-, 12-, 18- and 24-months post-index, defined as proportion of days covered ≥ 80% (secondary), and time-to-initiation of triple therapy (exploratory). Inverse probability of treatment weighting (IPTW) was used to balance potential confounding baseline characteristics. Superiority of UMEC/VI versus TIO/OLO for the primary outcome of rescue medication prescriptions was assessed using an intention-to-treat analysis with a p-value < 0.05. Results: In total, 8603 patients were eligible (UMEC/VI: n = 6536; TIO/OLO: n = 2067). Following IPTW, covariates were well balanced across groups. Patients initiating UMEC/VI had statistically significantly fewer (mean [standard deviation]; p-value) rescue medication prescriptions versus TIO/OLO in both the unweighted (4.84 [4.78] vs 5.68 [5.00]; p < 0.001) and weighted comparison (4.91 [4.81] vs 5.48 [5.02]; p = 0.0032) at 12 months; consistent results were seen at all timepoints. Adherence was numerically higher for TIO/OLO versus UMEC/VI at all timepoints. Time-to-triple therapy was similar between treatment groups. Conclusion: UMEC/VI was superior to TIO/OLO in reducing rescue medication prescriptions at 12 months after treatment initiation in a primary care cohort in England, potentially suggesting improvements in symptom control with UMEC/VI compared with TIO/OLO.
DOI:doi:10.2147/COPD.S411437
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.2147/COPD.S411437
 kostenfrei: Volltext: https://www.dovepress.com/comparison-of-rescue-medication-prescriptions-in-patients-with-chronic-peer-reviewed-fulltext- ...
 DOI: https://doi.org/10.2147/COPD.S411437
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1857223276
Verknüpfungen:→ Zeitschrift

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